Abstract
A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.
Original language | English |
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Pages (from-to) | 3474-3481 |
Number of pages | 8 |
Journal | Chemistry - A European Journal |
Volume | 7 |
Issue number | 16 |
DOIs | |
State | Published - 17 Aug 2001 |
Keywords
- Alkali metals
- Ion channels
- Ionophores
- Planar lipid bilayer
- Resorcin[4]arenes