Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Angela J. Wright; Susan E. Matthews; Wolfgang B. Fischer; Paul D. Beer

doi:10.1002/1521-3765(20010817)7:16<3474::AID-CHEM3474>3.0.CO;2-6

Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Angela J. Wright, Susan E. Matthews, Wolfgang B. Fischer, Paul D. Beer^*

^*Corresponding author for this work

Institute of Biophotonics

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K⁺ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K⁺/Na⁺ selectivity.

Original language	English
Pages (from-to)	3474-3481
Number of pages	8
Journal	Chemistry - A European Journal
Volume	7
Issue number	16
DOIs	https://doi.org/10.1002/1521-3765(20010817)7:16<3474::AID-CHEM3474>3.0.CO;2-6
State	Published - 17 Aug 2001

Keywords

Alkali metals
Ion channels
Ionophores
Planar lipid bilayer
Resorcin[4]arenes

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10.1002/1521-3765(20010817)7:16<3474::AID-CHEM3474>3.0.CO;2-6

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title = "Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics",

abstract = "A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.",

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AU - Matthews, Susan E.

AU - Fischer, Wolfgang B.

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AB - A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.

KW - Alkali metals

KW - Ion channels

KW - Ionophores

KW - Planar lipid bilayer

KW - Resorcin[4]arenes

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Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Abstract

Keywords

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