Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics

Angela J. Wright, Susan E. Matthews, Wolfgang B. Fischer, Paul D. Beer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

A series of novel resorcin[4]arenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.

Original languageEnglish
Pages (from-to)3474-3481
Number of pages8
JournalChemistry - A European Journal
Volume7
Issue number16
DOIs
StatePublished - 17 Aug 2001

Keywords

  • Alkali metals
  • Ion channels
  • Ionophores
  • Planar lipid bilayer
  • Resorcin[4]arenes

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