A series of novel resorcinarenes with extended π systems have been synthesised and developed as potassium-selective transporters. Resorcinarenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzocrown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.
|Number of pages||8|
|Journal||Chemistry - A European Journal|
|State||Published - 17 Aug 2001|
- Alkali metals
- Ion channels
- Planar lipid bilayer