Novel Monodisperse FePt Nanocomposites for T2-Weighted Magnetic Resonance Imaging: Biomedical Theranostics Applications

Zhi-Xuan Chang, Chien-Hsiu Li, Yu-Chan Chang, Chi-Ying Huang, Ming-Hsien Chan*, Michael Hsiao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Given the high incidence and mortality of cancer, current research is focused on designing efficient diagnostic methods. At present, clinical diagnoses are made based on X-ray, computed tomography, magnetic resonance imaging (MRI), ultrasound, and fiber optic endoscopy. MRI is a powerful diagnostic tool because it is non-invasive, has a high spatial resolution, uses non-ionizing radiation, and has good soft-tissue contrast. However, the long relaxation time of water protons may result in the inability to distinguish different tissues. To overcome this drawback of MRI, magnetic resonance contrast agents can enhance the contrast, improve the sensitivity of MRI-based diagnoses, increase the success rate of surgery, and reduce tumor recurrence. This review focuses on using iron-platinum (FePt) nanoparticles (NPs) in T2-weighted MRI to detect tumor location based on dark-field changes. In addition, existing methods for optimizing and improving FePt NPs are reviewed, and the MRI applications of FePt NPs are discussed. FePT NPs are expected to strengthen MRI resolution, thereby helping to inhibit tumor development.
Original languageEnglish
Pages (from-to)377-386
Number of pages11
JournalNanoscale Advances
Volume4
Issue number2
DOIs
StatePublished - Nov 2021

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