Nonpolar Side Chains Affect the Photochemical Redox Reactions of Copper(II)-Amino Acid Complexes in Aqueous Solutions

Chen Jui Lin, Po Yen Wang, Yi Liang Lin, Sheng Te Chang, Chao Sheng Hsu, Shu Pao Wu, Chien Hou Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Photochemical redox reactions of Cu(II) complexes of eight amino acid ligands (L) with nonpolar side chains have been systematically investigated in deaerated aqueous solutions. Under irradiation at 313 nm, the intramolecular carboxylate-to-Cu(II) charge transfer within Cu(II)-amino acid complexes leads to Cu(I) formation and the concomitant decomposition of amino acids. All amino acid systems studied here can produce ammonia and aldehydes except proline. For the 1:1 Cu(II) complex species (CuL), the Cu(I) quantum yields at 313 nm (φCu(I),CuL) vary by fivefold and in the sequence (0.10 M ionic strength at 25 °C) alanine (0.094) > valine (0.059), leucine (0.059), isoleucine (0.056), phenylalanine (0.057) > glycine (0.052) > methionine (0.032) > proline (0.019). This trend can be rationalized by considering the stability of the carbon-centered radicals and the efficient depopulation of the photoexcited state, both of which are dependent on the side-chain structure. For the 1:2 Cu(II) complex species (CuL2), the Cu(I) quantum yields exhibit a similar trend and are always less than those for CuL. The photoformation rates of ammonia, Cu(I), and aldehydes are in the ratio of 1:2.0 ± 0.2:0.7 ± 0.2, which supports the proposed mechanism. This study suggests that the direct phototransformation of Cu(II)-amino acid complexes may contribute to the bioavailable nitrogen for aquatic microorganisms and cause biological damage on cell surfaces in sunlit waters.

Original languageEnglish
Pages (from-to)28194-28202
Number of pages9
JournalACS Omega
Volume6
Issue number42
DOIs
StatePublished - 26 Oct 2021

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