Noninvasive glucose monitoring in vivo with an optical heterodyne polarimeter

Chien Chou*, Chien Yuan Han, Wen Chuan Kuo, Yeu Chuen Huang, Ching Mei Feng, Jenn Chyang Shyu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


An amplitude-sensitive optical heterodyne polarimeter was set up to monitor noninvasively the aqueous glucose concentration in a rabbit's eye. A Zeeman laser in conjunction with a Clan-Thompson analyzer was used to generate an optical heterodyne signal. The amplitude of the heterodyne signal linearly related to the optical rotation angle of the aqueous glucose. The concentration of the aqueous glucose in a rabbit's eyeball was measured in vivo. There was a 30-min time delay between observations of aqueous glucose and blood glucose. The detection capability and the reproducibility of the experiment are demonstrated and discussed.

Original languageEnglish
Pages (from-to)3553-3557
Number of pages5
JournalApplied Optics
Issue number16
StatePublished - 1998


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