TY - JOUR
T1 - Non-pharmacological treatment reducing not only behavioral symptoms, but also psychotic symptoms of older adults with dementia
T2 - A prospective cohort study in Taiwan
AU - Chen, Rue Chuan
AU - Liu, Chien Liang
AU - Lin, Ming Hsien
AU - Peng, Li Ning
AU - Chen, Liang Yu
AU - Liu, Li Kuo
AU - Chen, Liang Kung
PY - 2014
Y1 - 2014
N2 - Aim: The clinical effectiveness of non-pharmacological interventions on behavioral and psychological symptoms of dementia (BPSD) among older Chinese with dementia remains unclear, and the evidence supporting the benefits of a non-pharmacological approach on psychotic symptoms is scarce. Methods: A prospective cohort study including 104 older men with dementia living in two veterans homes in Taiwan was carried out in 2011. An organized program of music therapy, orientation training, art-cognitive activities and physical activities was carried out for the intervention group. All participants were evaluated for neuropsychiatric inventory (NPI), defined daily dose of psychotropic drug use, Barthel Index, Instrumental Activities of Daily Living, Mini-Mental State Examination, Geriatric Depression Scale, Tinetti balance score and Tinetti gait score. Results: Overall, 104 residents were enrolled and 92 of them completed the study. The intervention group had a more significant reduction than the reference group in the overall NPI score (-2.36, P=0.046), and in the subcategories of delusion (-0.9, P=0.018), hallucination (-0.82, P=0.004) and agitation (-0.91, P=0.038). Multivariate analysis showed that the non-pharmacological intervention was associated with a favorable outcome in overall NPI score (OR 4.113, P=0.013) and in the subcategories of hallucination (OR 14.309, P=0.049) and agitation (OR 6.604, P=0.037). Meanwhile, a higher baseline NPI score was also associated with a favorable outcome in overall NPI score, and in the subcategories of delusion, hallucination and agitation. Conclusion: Non-pharmacological interventions have a positive effect on behavioral and psychological symptoms of dementia, not only in outward symptoms like agitation, but also intrinsic psychotic symptoms like hallucination and delusion, and agitation in older Chinese men with dementia.
AB - Aim: The clinical effectiveness of non-pharmacological interventions on behavioral and psychological symptoms of dementia (BPSD) among older Chinese with dementia remains unclear, and the evidence supporting the benefits of a non-pharmacological approach on psychotic symptoms is scarce. Methods: A prospective cohort study including 104 older men with dementia living in two veterans homes in Taiwan was carried out in 2011. An organized program of music therapy, orientation training, art-cognitive activities and physical activities was carried out for the intervention group. All participants were evaluated for neuropsychiatric inventory (NPI), defined daily dose of psychotropic drug use, Barthel Index, Instrumental Activities of Daily Living, Mini-Mental State Examination, Geriatric Depression Scale, Tinetti balance score and Tinetti gait score. Results: Overall, 104 residents were enrolled and 92 of them completed the study. The intervention group had a more significant reduction than the reference group in the overall NPI score (-2.36, P=0.046), and in the subcategories of delusion (-0.9, P=0.018), hallucination (-0.82, P=0.004) and agitation (-0.91, P=0.038). Multivariate analysis showed that the non-pharmacological intervention was associated with a favorable outcome in overall NPI score (OR 4.113, P=0.013) and in the subcategories of hallucination (OR 14.309, P=0.049) and agitation (OR 6.604, P=0.037). Meanwhile, a higher baseline NPI score was also associated with a favorable outcome in overall NPI score, and in the subcategories of delusion, hallucination and agitation. Conclusion: Non-pharmacological interventions have a positive effect on behavioral and psychological symptoms of dementia, not only in outward symptoms like agitation, but also intrinsic psychotic symptoms like hallucination and delusion, and agitation in older Chinese men with dementia.
KW - Agitation
KW - Behavioral and psychiatric symptoms of dementia
KW - Delusion
KW - Dementia
KW - Hallucination
KW - Non-pharmacological interventions
UR - http://www.scopus.com/inward/record.url?scp=84897547455&partnerID=8YFLogxK
U2 - 10.1111/ggi.12126
DO - 10.1111/ggi.12126
M3 - Article
C2 - 23910097
AN - SCOPUS:84897547455
SN - 1444-1586
VL - 14
SP - 440
EP - 446
JO - Geriatrics and Gerontology International
JF - Geriatrics and Gerontology International
IS - 2
ER -