No evidence for linkage of bipolar disorder to markers on chromosome 13 in Taiwanese pedigrees

M. W. Lin*, W. C. Ou-Yang, S. F.C. Lee, H. G. Hwu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Bipolar disorder is a complex disorder with a lifetime prevalence ranging from 0.5 -1.5%. Family, twin, adoption studies showed evidence supporting the existence of genes predisposing to bipolar disorder. Linkage studies have shown suggestive evidence on chromosome 4,12q23-24, 18, 21q22. Significant linkage evidence between bipolar disorder and chromosome 13q32 was reported recently. Suggestive link-age evidence between schizophrenia and chromosome 13q32 was first reported by our group and further by other groups. In order to verify if bipolar disorder and schizophrenia share susceptibility regions, we collected nine families with two sibs affected with bipolar disorder and ten families with at least one sib affected with bipolar disorder and one sib affected with schizophrenia for linkage analysis on twelve markers of chromosome 13. Linkage analysis was performed by using the LINKAGE (FASTLINK v4.0) and the GENE-HUNRER (version 1.2). No positive evidence of linkage was obtained by both two-point and multipoint analysis. Our results suggest that there is no linkage evidence between markers on chromosome 13 and bipolar disorder. Our findings also suggest that it is unlikely that bipolar disorder and schizophrenia share the same susceptibility regions on chromosome 13q32 in our Taiwanese pedigrees.

Original languageEnglish
Pages (from-to)546
Number of pages1
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume96
Issue number4
StatePublished - 7 Aug 2000

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