@inproceedings{d1a2c97790b649508695fcea697553ec,
title = "New quantitative approach to analyze capillary permeability data that combines junctional pores and a fiber layer at the cleft entrance",
abstract = "A three dimensional junction-pore-matrix model is applied to examine the role of the intercellular junction and matrix structures in the regulation of capillary permeability. In this studies a new hydrodynamic theory has been developed to examine the effect of a thin fiber layer at the entrance of the cleft. The fiber matrix structure is represented by either a perpendicular array of cylindrical posts or a porous medium with parallel channels running perpendicular to the lumen front at the entrance of the cleft. Our results indicate that a cleft with large junctional gaps of 22×44 nm and gap spacing of 480 nm and a fiber matrix with open spacing Δ ≈ 7nm can fit the measured values for solute permeability for small ions and large molecules of the size close to albumin and the values for hydraulic conductivities with and without a surface fiber layer present. However, it can not also fit the measured values of solute permeability for the intermediate size solutes. Therefore, it is clear that by considering the hydrodynamic forces alone, a cleft with uniform size junctional pores and a fiber matrix layer does not offer enough diffusive resistance for the intermediate size solutes.",
author = "Tsay, {Ruey Yug} and Curry, {Fitz Roy E.} and Sheldon Weinbaum",
year = "1991",
language = "English",
isbn = "0791808785",
series = "American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD",
publisher = "Publ by ASME",
pages = "43--49",
booktitle = "Advances in Biological Heat and Mass Transfer",
note = "Winter Annual Meeting of the American Society of Mechanical Engineers ; Conference date: 01-12-1991 Through 06-12-1991",
}