Neuroprotective effects of longan (Dimocarpus longan Lour.) flower water extract on MPP+-induced neurotoxicity in rat brain

Anya Maan Yuh Lin*, Liang Yi Wu, Kai Chih Hung, Hui Ju Huang, Yen Ping Lei, Wen Chien Lu, Lucy Sun Hwang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In this study, the neuroprotective effect of Dimocarpus longan Lour. flower water extract (LFWE) was investigated. First, an in vitro study showed that LFWE concentration-dependently inhibited lipid peroxidation of brain homogenates incubated at 37 °C. The antioxidative activity of LFWE was more potent than that of glutathione or Trolox. Furthermore, an ex vivo study found that the basal lipid peroxidation (0 °C) and lipid peroxidation incubated at 37 °C were lower in the brain homogenates of LFWE-treated (500 mg/day) rats, indicating that the brain of LFWE-treated rats was more resistant to oxidative stress. Moreover, a Parkinsonian animal model was employed to demonstrate that oral administration of LFWE (125-500 mg/kg/day) dose-dependently attenuated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in the nigrostriatal dopaminergic system of rat brain. In conclusion, this study suggests that LFWE is antioxidative, anti-inflammatory, and anti-apoptotic. Furthermore, oral administration of LFWE appears to be useful in preventing and/or treating central nervous system neurodegenerative diseases, including Parkinsonism.

Original languageEnglish
Pages (from-to)9188-9194
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume60
Issue number36
DOIs
StatePublished - 12 Sep 2012

Keywords

  • α-synuclein aggregation
  • anti-apoptosis
  • anti-inflammation
  • Dimocarpus longan Lour.
  • MPP+
  • neurotoxicity
  • oxidative stress

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