Neuroimaging studies of primary dysmenorrhea

Intan Low, Shyh Yuh Wei, Pin Shiuan Lee, Wei Chi Li, Lin Chien Lee, Jen Chuen Hsieh*, Li Fen Chen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

18 Scopus citations


Primary dysmenorrhea (PDM), cyclic menstrual pain in the absence of pelvic anomalies, is one of the most common gynecological disorders in reproductive females. Classified as chronic pelvic pain syndrome, PDM encompasses recurrent spontaneous painful (“on”) and pain-free (“off”) states and is thus a good clinical model to study state- and trait-related changes of pain in the brain. In this chapter, we summarize state-of-the-art neuroimaging studies of primary dysmenorrhea from phenotype and endophenotype to genotype facets. Structural and functional brain alterations associated with primary dysmenorrhea are discussed.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages21
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Chronic pelvic pain
  • Descending pain modulatory system
  • Genetic polymorphism
  • Neuroplasticity
  • Primary dysmenorrhea
  • Resting-state


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