TY - JOUR
T1 - Near-Infrared Windows I and II Phosphors for Theranostic Applications
T2 - Spectroscopy, Bioimaging, and Light-Emitting Diode Photobiomodulation
AU - Huang, Wen Tse
AU - Rajendran, Veeramani
AU - Chan, Ming Hsien
AU - Hsiao, Michael
AU - Chang, Ho
AU - Liu, Ru Shi
N1 - Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2022
Y1 - 2022
N2 - The importance and practicality of near-infrared (NIR) light for the biomedical field has attached importance to the academe and industry with the development of technology. Luminescent materials with different doping strategies are promising candidates for covering near-infrared biological windows from 700 nm to 1 700 nm. The relationship between NIR light, nanophosphors, and biological tissue towards the function of diagnostic and therapy in different NIR windows is explored clearly, which corresponds to diffuse reflection spectroscopy with bioimaging and light-emitting diode (LED) photobiomodulation. The diseases can be monitored with specific chromophore absorption under the NIR light source, which also can be traced to the dynamic change of the biological environment by luminescent materials. Especially in brain diseases, cytochrome c oxidase in mitochondria as the crucial photoreceptor can be activated under NIR irradiation to achieve the non-invasive treatment of neuron protection and recovery. NIR light attributed to LED or nanophosphors show the potential of theranostic approaches in biomedical technology. Cr3+- and Ni2+-activated phosphors covering NIR windows I and II are presented with optical properties to explore the feasibility and practicability of non-invasive precise medical treatment in the future.
AB - The importance and practicality of near-infrared (NIR) light for the biomedical field has attached importance to the academe and industry with the development of technology. Luminescent materials with different doping strategies are promising candidates for covering near-infrared biological windows from 700 nm to 1 700 nm. The relationship between NIR light, nanophosphors, and biological tissue towards the function of diagnostic and therapy in different NIR windows is explored clearly, which corresponds to diffuse reflection spectroscopy with bioimaging and light-emitting diode (LED) photobiomodulation. The diseases can be monitored with specific chromophore absorption under the NIR light source, which also can be traced to the dynamic change of the biological environment by luminescent materials. Especially in brain diseases, cytochrome c oxidase in mitochondria as the crucial photoreceptor can be activated under NIR irradiation to achieve the non-invasive treatment of neuron protection and recovery. NIR light attributed to LED or nanophosphors show the potential of theranostic approaches in biomedical technology. Cr3+- and Ni2+-activated phosphors covering NIR windows I and II are presented with optical properties to explore the feasibility and practicability of non-invasive precise medical treatment in the future.
KW - bioimaging
KW - diffuse reflection spectroscopy
KW - near-infrared windows
KW - phosphor-converted light-emitting diodes
KW - photobiomodulation
UR - http://www.scopus.com/inward/record.url?scp=85144294129&partnerID=8YFLogxK
U2 - 10.1002/adom.202202061
DO - 10.1002/adom.202202061
M3 - Review article
AN - SCOPUS:85144294129
SN - 2195-1071
JO - Advanced Optical Materials
JF - Advanced Optical Materials
ER -