Natural History of Persistent Pulmonary Subsolid Nodules: Long-Term Observation of Different Interval Growth

En Kuei Tang, Chi Shen Chen, Carol C. Wu, Ming Ting Wu, Tseng Lung Yang, Huei Lung Liang, Hui Ting Hsu, Fu Zong Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Background: The long-term natural course and outcomes of subsolid nodules (SSNs) in terms of true growth, substantial growth, and stage shift need to be clarified. Methods: Between 2002 and 2016, 128 subjects with persistent SSNs of 3 cm or smaller were enrolled. The baseline and interval changes in the series computed tomography (CT) findings during the follow-up period were subsequently reviewed. Results: The mean follow-up period was 3.57 ± 2.93 years. The cumulative percentage of growth nodules of the part-solid nodule (PSN) group was significantly higher than that of the ground-glass nodule (GGN) group by Kaplan-Meier estimation (all p < 0.0001). For true SSN growth, GGNs usually take a median follow-up of 7 years to grow; PSNs usually take a median follow-up of 3 years to grow. For substantial SSN growth, GGNs usually take a median follow-up of 9 years to grow; PSNs usually take a median follow-up of 3 years to grow. For stage shift, GGNs usually take a median follow-up of 12 years to grow; PSNs usually take a median follow-up of 9 years to grow. Conclusions: The natural course in terms of true growth, substantial growth, and stage shift differed significantly according to their nodule type, which could contribute to the development of follow-up guidelines and management strategy of pulmonary SSNs.

Original languageEnglish
Pages (from-to)1747-1754
Number of pages8
JournalHeart Lung and Circulation
Volume28
Issue number11
DOIs
StatePublished - Nov 2019

Keywords

  • Ground-glass nodule
  • Lung adenocarcinoma
  • Natural course
  • Part-solid nodule
  • Subsolid nodule

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