Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation

Chi Chang Wu; Fu-Hsiang Ko; Ting Siang Su; Bo Syuan Li; Wen Fa Wu

doi:10.1109/INEC.2010.5425155

Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation

Chi Chang Wu, Fu-Hsiang Ko^*, Ting Siang Su, Bo Syuan Li, Wen Fa Wu

^*Corresponding author for this work

Institute of Nonotechnology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.

Original language	English
Title of host publication	INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings
Pages	872-873
Number of pages	2
DOIs	https://doi.org/10.1109/INEC.2010.5425155
State	Published - 5 May 2010
Event	2010 3rd International Nanoelectronics Conference, INEC 2010 - Hongkong, China Duration: 3 Jan 2010 → 8 Jan 2010

Publication series

Name	INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings

Conference

Conference	2010 3rd International Nanoelectronics Conference, INEC 2010
Country/Territory	China
City	Hongkong
Period	3/01/10 → 8/01/10

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10.1109/INEC.2010.5425155

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Wu, C. C., Ko, F.-H., Su, T. S., Li, B. S., & Wu, W. F. (2010). Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. In INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings (pp. 872-873). Article 5425155 (INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings). https://doi.org/10.1109/INEC.2010.5425155

@inproceedings{879cfc5408254c5e9af23c36d3cdfe4e,

title = "Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation",

abstract = "We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.",

author = "Wu, {Chi Chang} and Fu-Hsiang Ko and Su, {Ting Siang} and Li, {Bo Syuan} and Wu, {Wen Fa}",

year = "2010",

month = may,

day = "5",

doi = "10.1109/INEC.2010.5425155",

language = "English",

isbn = "9781424435449",

series = "INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings",

pages = "872--873",

booktitle = "INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings",

note = "2010 3rd International Nanoelectronics Conference, INEC 2010 ; Conference date: 03-01-2010 Through 08-01-2010",

}

Wu, CC, Ko, F-H, Su, TS, Li, BS & Wu, WF 2010, Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. in INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings., 5425155, INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings, pp. 872-873, 2010 3rd International Nanoelectronics Conference, INEC 2010, Hongkong, China, 3/01/10. https://doi.org/10.1109/INEC.2010.5425155

Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation. / Wu, Chi Chang; Ko, Fu-Hsiang; Su, Ting Siang et al.
INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings. 2010. p. 872-873 5425155 (INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation

AU - Wu, Chi Chang

AU - Ko, Fu-Hsiang

AU - Su, Ting Siang

AU - Li, Bo Syuan

AU - Wu, Wen Fa

PY - 2010/5/5

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N2 - We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.

AB - We describe the efficiency of deoxyribonucleic acid (DNA) immobilization onto a nanowire (NW) after employing various surface cleaning methods. From surface tension measurements and fluorescence microscopy images of the silicon oxide surfaces, we determined that the effectiveness of surface cleaning using an acetone/ethanol mixture was similar to that of piranha solution (sulfuric acid/hydrogen peroxide). Thus, we employed surface cleaning with an acetone/ethanol mixture en route toward the fabrication of a series of label-free, back-gated, 60-nm nanowire field-effect transistor (NWFET) sensors for the detection of the BRAFV599E oncogene. We applied the NWFET sensor to the successful detection of the hybridization and dehybridization processes of the BRAFV599E mutation gene.

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M3 - Conference contribution

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T3 - INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings

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Nanowire field effect transistor with its sub-picomolar label-free biosensing capability toward a gene mutation

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