Nanoporous materials for biomedical devices

Shashishekar P. Adiga; Larry A. Curtiss; Jeffrey W. Elam; Michael J. Pellin; Chun Che Shih; Chun Ming Shih; Shing Jong Lin; Yea Yang Su; Shaun D. Gittard; Junping Zhang; Roger J. Narayan

doi:10.1007/s11837-008-0028-9

Nanoporous materials for biomedical devices

Shashishekar P. Adiga^*, Larry A. Curtiss, Jeffrey W. Elam, Michael J. Pellin, Chun Che Shih, Chun Ming Shih, Shing Jong Lin, Yea Yang Su, Shaun D. Gittard, Junping Zhang, Roger J. Narayan

^*Corresponding author for this work

Institute of Clinical Medicine

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

Nandporous materials are currently being developed for use in implantable drug delivery systems, bioartificial organs, and other novel medical devices. Advances in nanofabrication have made it possible to precisely control the pore size, pore distribution, porosity, and chemical properties of pores in nanoporous materials. As a result, these materials are attractive for regulating and sensing transport at the molecular level. In this work, the use of nanoporous membranes for biomedical applications is reviewed. The basic concepts underlying membrane transport are presented in the context of design considerations for efficient size sorting. Desirable properties of nanoporous membranes used in implantable devices, including biocompatibility and antibiofouling behavior are also discussed. In addition, the use of surface modification techniques to improve the function of nanoporous membranes is reviewed. An intriguing possibility involves functionalizing nanoporous materials with smart polymers in order to modulate biomolecular transport in response to pH, temperature, ionic concentration, or other stimuli. These efforts open up avenues to develop smart medical devices that respond to specific physiological conditions.

Original language	English
Pages (from-to)	26-32
Number of pages	7
Journal	JOM
Volume	60
Issue number	3
DOIs	https://doi.org/10.1007/s11837-008-0028-9
State	Published - Mar 2008

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@article{2d29425010474ea6ac3497cd05296b81,

title = "Nanoporous materials for biomedical devices",

abstract = "Nandporous materials are currently being developed for use in implantable drug delivery systems, bioartificial organs, and other novel medical devices. Advances in nanofabrication have made it possible to precisely control the pore size, pore distribution, porosity, and chemical properties of pores in nanoporous materials. As a result, these materials are attractive for regulating and sensing transport at the molecular level. In this work, the use of nanoporous membranes for biomedical applications is reviewed. The basic concepts underlying membrane transport are presented in the context of design considerations for efficient size sorting. Desirable properties of nanoporous membranes used in implantable devices, including biocompatibility and antibiofouling behavior are also discussed. In addition, the use of surface modification techniques to improve the function of nanoporous membranes is reviewed. An intriguing possibility involves functionalizing nanoporous materials with smart polymers in order to modulate biomolecular transport in response to pH, temperature, ionic concentration, or other stimuli. These efforts open up avenues to develop smart medical devices that respond to specific physiological conditions.",

author = "Adiga, {Shashishekar P.} and Curtiss, {Larry A.} and Elam, {Jeffrey W.} and Pellin, {Michael J.} and Shih, {Chun Che} and Shih, {Chun Ming} and Lin, {Shing Jong} and Su, {Yea Yang} and Gittard, {Shaun D.} and Junping Zhang and Narayan, {Roger J.}",

note = "Funding Information: This work is supported in part by the U.S. Department of Energy{\textquoteright}s Office of Basic Energy Sciences, under contract no. DE-AC02-06CH11357. Also, support from the National Institute of Biomedical Imaging and BioEngineering (5R21EB003090) is acknowledged.",

year = "2008",

month = mar,

doi = "10.1007/s11837-008-0028-9",

language = "English",

volume = "60",

pages = "26--32",

journal = "JOM",

issn = "1047-4838",

publisher = "Minerals, Metals and Materials Society",

number = "3",

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AU - Adiga, Shashishekar P.

AU - Curtiss, Larry A.

AU - Elam, Jeffrey W.

AU - Pellin, Michael J.

AU - Shih, Chun Che

AU - Shih, Chun Ming

AU - Lin, Shing Jong

AU - Su, Yea Yang

AU - Gittard, Shaun D.

AU - Zhang, Junping

AU - Narayan, Roger J.

N1 - Funding Information: This work is supported in part by the U.S. Department of Energy’s Office of Basic Energy Sciences, under contract no. DE-AC02-06CH11357. Also, support from the National Institute of Biomedical Imaging and BioEngineering (5R21EB003090) is acknowledged.

PY - 2008/3

Y1 - 2008/3

N2 - Nandporous materials are currently being developed for use in implantable drug delivery systems, bioartificial organs, and other novel medical devices. Advances in nanofabrication have made it possible to precisely control the pore size, pore distribution, porosity, and chemical properties of pores in nanoporous materials. As a result, these materials are attractive for regulating and sensing transport at the molecular level. In this work, the use of nanoporous membranes for biomedical applications is reviewed. The basic concepts underlying membrane transport are presented in the context of design considerations for efficient size sorting. Desirable properties of nanoporous membranes used in implantable devices, including biocompatibility and antibiofouling behavior are also discussed. In addition, the use of surface modification techniques to improve the function of nanoporous membranes is reviewed. An intriguing possibility involves functionalizing nanoporous materials with smart polymers in order to modulate biomolecular transport in response to pH, temperature, ionic concentration, or other stimuli. These efforts open up avenues to develop smart medical devices that respond to specific physiological conditions.

AB - Nandporous materials are currently being developed for use in implantable drug delivery systems, bioartificial organs, and other novel medical devices. Advances in nanofabrication have made it possible to precisely control the pore size, pore distribution, porosity, and chemical properties of pores in nanoporous materials. As a result, these materials are attractive for regulating and sensing transport at the molecular level. In this work, the use of nanoporous membranes for biomedical applications is reviewed. The basic concepts underlying membrane transport are presented in the context of design considerations for efficient size sorting. Desirable properties of nanoporous membranes used in implantable devices, including biocompatibility and antibiofouling behavior are also discussed. In addition, the use of surface modification techniques to improve the function of nanoporous membranes is reviewed. An intriguing possibility involves functionalizing nanoporous materials with smart polymers in order to modulate biomolecular transport in response to pH, temperature, ionic concentration, or other stimuli. These efforts open up avenues to develop smart medical devices that respond to specific physiological conditions.

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SP - 26

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Nanoporous materials for biomedical devices

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