NAFLD aggravates septic shock due to inadequate adrenal response and 11β-HSDS dysregulation in rats

Hui Chun Huang, Ming Hung Tsai, Fa Yauh Lee, Te Yueh Lin, Ching Chih Chang, Chiao Lin Chuang, Shao Jung Hsu*, Ming Chih Hou, Yi Hsiang Huang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is linked with metabolic syndrome. Previous studies showed that obesity may disrupt adrenal function and adversely affect its counter-regulations against shock. This study hence evaluated adrenal function abnormalities in NAFLD with shock. Methods: Sprague-Dawley rats were fed with regular chow-diet (control) or high fat diet (HFD, 60% energy derived from fat). Blood tests were performed at the end of the 4th, 6th and 8th week, respectively. Experiments were performed at the end of the 8th week. Results: HFD rats developed NAFLD. HFD rats had 27% and 51% increase in plasma corticosterone at the 6th and 8th week in usual status. However, HFD rats had 5 times more reduction of mean arterial pressure in response to lipopolysaccharide-induced sepsis as compared to control rats. The corticosterone increment ratio was also lower in HFD rats, even after ACTH administration. 11β-HSD system tended to generate more corticosterone in HFD rats under hemodynamic stable status without shock and the trend was lost in HFD rats with septic shock. Conclusion: Rats with NAFLD had profound septic shock due to inadequate corticosterone response. This is, at least partly, due to 11β-HSDs dysregulation in sepsis.

Original languageEnglish
Article number403
JournalPharmaceutics
Volume12
Issue number5
DOIs
StatePublished - May 2020

Keywords

  • 11β-HSD1
  • Adrenal function
  • Non-alcoholic fatty liver disease
  • Shock

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