Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

Chia-Wei Sun; Yih Ming Wang; Long Sheng Lu; Chih Wei Lu; I. Jen Hsu; Meng Tsan Tsai; C. C. Yang; Yean Woei Kiang; Chau Chung Wu

doi:10.1117/1.2363358

Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

Chia-Wei Sun, Yih Ming Wang, Long Sheng Lu, Chih Wei Lu, I. Jen Hsu, Meng Tsan Tsai, C. C. Yang^*, Yean Woei Kiang, Chau Chung Wu

^*Corresponding author for this work

Department of Photonics

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.

Original language	English
Article number	054016
Journal	Journal of Biomedical Optics
Volume	11
Issue number	5
DOIs	https://doi.org/10.1117/1.2363358
State	Published - Sep 2006

Keywords

Lasers
Medical imaging
Microscopy
Optical systems
Polarization

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10.1117/1.2363358

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title = "Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser",

abstract = "A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.",

keywords = "Lasers, Medical imaging, Microscopy, Optical systems, Polarization",

author = "Chia-Wei Sun and Wang, {Yih Ming} and Lu, {Long Sheng} and Lu, {Chih Wei} and Hsu, {I. Jen} and Tsai, {Meng Tsan} and Yang, {C. C.} and Kiang, {Yean Woei} and Wu, {Chau Chung}",

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T1 - Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

AU - Sun, Chia-Wei

AU - Wang, Yih Ming

AU - Lu, Long Sheng

AU - Lu, Chih Wei

AU - Hsu, I. Jen

AU - Tsai, Meng Tsan

AU - Yang, C. C.

AU - Kiang, Yean Woei

AU - Wu, Chau Chung

PY - 2006/9

Y1 - 2006/9

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AB - A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.

KW - Lasers

KW - Medical imaging

KW - Microscopy

KW - Optical systems

KW - Polarization

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JF - Journal of Biomedical Optics

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ER -

Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

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