TY - JOUR
T1 - Myocardial injury was associated with neurological sequelae of acute carbon monoxide poisoning in Taiwan
AU - Lin, Mau Sheng
AU - Lin, Chun Chi
AU - Yang, Chen Chang
AU - Weng, Shu Chuan
AU - Wang, Shun Mu
AU - Chen, Chuan Yu
AU - Huang, Nicole
AU - Chou, Yuan Hwa
N1 - Publisher Copyright:
© 2018
PY - 2018/8
Y1 - 2018/8
N2 - Background: Carbon monoxide (CO) poisoning has recently become a serious health problem in some Asian countries, including Taiwan. The aims of this study are to evaluate the changing trend of CO poisoning and to demonstrate the association between myocardial injury and neurological sequelae of CO poisoning in Taiwan between 1990 and 2011. Methods: This retrospective cohort study included all eligible patients with acute CO poisoning reported to the Taiwan National Poison Control Center during the study period. The changing trend of CO poisoning and its impacts on the primary outcomes, i.e., persistent neurological sequelae (PNS) and delayed neurological sequelae (DNS), were then assessed. Results: 786 CO poisoned cases were reported. Among them, 467 cases were intentional. Intentional CO exposure started to become the major cause of CO poisoning in Taiwan in 2002. Increase in the number of intentional CO poisoning significantly correlated with the increase in the overall number of CO poisoning (r = 0.972, p < 0.001). Patients who took tranquilizer (OR = 3.89; 95% CI:1.94–7.77), had myocardial injury (OR = 1.70; 95% CI:1.03–2.82), had been stayed in intensive care unit (OR = 2.03; 95% CI:1.13–3.62), presented with GCS less than 9 (OR = 4.05; 95% CI:2.32–7.08) and had abnormal brain image (OR = 14.46; 95% CI:5.83–35.83) had a higher risk of PNS. Moreover, patients who were older age (OR = 1.04; 95% CI:1.02–1.07), had psychiatric disorder history (OR = 2.82; 95% CI:1.35–5.89), had myocardial injury (OR = 1.33; 95% CI:1.16–1.53), and presented with GCS less than 9 (OR = 3.23; 95% CI:1.65–6.34) had a higher risk of DNS. Conclusion: The pattern of CO poisoning had changed markedly during the study period, with a significant increase in both the numbers of intentional and overall CO poisoning. Moreover, intentional CO poisoning was associated with a higher risk of neurological sequelae, which was mediated by various indicators of poisoning severity such as myocardial injury and GCS less than 9.
AB - Background: Carbon monoxide (CO) poisoning has recently become a serious health problem in some Asian countries, including Taiwan. The aims of this study are to evaluate the changing trend of CO poisoning and to demonstrate the association between myocardial injury and neurological sequelae of CO poisoning in Taiwan between 1990 and 2011. Methods: This retrospective cohort study included all eligible patients with acute CO poisoning reported to the Taiwan National Poison Control Center during the study period. The changing trend of CO poisoning and its impacts on the primary outcomes, i.e., persistent neurological sequelae (PNS) and delayed neurological sequelae (DNS), were then assessed. Results: 786 CO poisoned cases were reported. Among them, 467 cases were intentional. Intentional CO exposure started to become the major cause of CO poisoning in Taiwan in 2002. Increase in the number of intentional CO poisoning significantly correlated with the increase in the overall number of CO poisoning (r = 0.972, p < 0.001). Patients who took tranquilizer (OR = 3.89; 95% CI:1.94–7.77), had myocardial injury (OR = 1.70; 95% CI:1.03–2.82), had been stayed in intensive care unit (OR = 2.03; 95% CI:1.13–3.62), presented with GCS less than 9 (OR = 4.05; 95% CI:2.32–7.08) and had abnormal brain image (OR = 14.46; 95% CI:5.83–35.83) had a higher risk of PNS. Moreover, patients who were older age (OR = 1.04; 95% CI:1.02–1.07), had psychiatric disorder history (OR = 2.82; 95% CI:1.35–5.89), had myocardial injury (OR = 1.33; 95% CI:1.16–1.53), and presented with GCS less than 9 (OR = 3.23; 95% CI:1.65–6.34) had a higher risk of DNS. Conclusion: The pattern of CO poisoning had changed markedly during the study period, with a significant increase in both the numbers of intentional and overall CO poisoning. Moreover, intentional CO poisoning was associated with a higher risk of neurological sequelae, which was mediated by various indicators of poisoning severity such as myocardial injury and GCS less than 9.
KW - Acute CO poisoning
KW - Charcoal-burning
KW - Delayed neurological sequelae
KW - Persistent neurological sequelae
UR - http://www.scopus.com/inward/record.url?scp=85047451842&partnerID=8YFLogxK
U2 - 10.1016/j.jcma.2017.12.006
DO - 10.1016/j.jcma.2017.12.006
M3 - Article
C2 - 29853349
AN - SCOPUS:85047451842
SN - 1726-4901
VL - 81
SP - 682
EP - 690
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
IS - 8
ER -