Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: Remission of refractory anemia following mycophenolate mofetil

J. T. Lin; W. S. Wang; C. C. Yen; T. J. Chiou; J. H. Liu; L. T. Hsiao; M. H. Yang; T. C. Chao; C. J. Tai; P. M. Chen

doi:10.1007/s00277-002-0539-3

Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: Remission of refractory anemia following mycophenolate mofetil

J. T. Lin, W. S. Wang, C. C. Yen, T. J. Chiou, J. H. Liu, L. T. Hsiao, M. H. Yang, T. C. Chao, C. J. Tai, P. M. Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Autoimmune hemolytic anemia (AIHA) rarely occurs in myelodysplastic syndrome (MDS). A 36-year-old Asian female was diagnosed with MDS (refractory cytopenia with multilineage dysplasia, RCMD) and complicated by AIHA 7 months later. Secondary myelofibrosis developed at the same time. Steroid therapy was ineffective and cyclosporin A (CsA) was discontinued due to its neurotoxicity with the development of leukoencephalopathy. However, the patient achieved a good hematological response after the use of mycophenolate mofetil (MMF, CellCept) with a dose of 1 g/day and prednisolone (15 mg/day). Prednisolone was tapered off over the next 3 weeks. The patient did not require any blood support 4 weeks after the use of MMF and has been hematologically stable for 4 months. To our knowledge, this is the first report of using MMF in treating MDS complicated by AIHA. MMF might be considered as a salvage therapy for patients with refractory anemia complicated by AIHA.

Original language	English
Pages (from-to)	723-726
Number of pages	4
Journal	Annals of Hematology
Volume	81
Issue number	12
DOIs	https://doi.org/10.1007/s00277-002-0539-3
State	Published - Dec 2002

Keywords

Autoimmune hemolytic anemia
Mycophenolate mofetil
Myelodysplastic syndrome

Access to Document

10.1007/s00277-002-0539-3

Cite this

@article{3387daef2b2c45e38b694c176eee9e9f,

title = "Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: Remission of refractory anemia following mycophenolate mofetil",

abstract = "Autoimmune hemolytic anemia (AIHA) rarely occurs in myelodysplastic syndrome (MDS). A 36-year-old Asian female was diagnosed with MDS (refractory cytopenia with multilineage dysplasia, RCMD) and complicated by AIHA 7 months later. Secondary myelofibrosis developed at the same time. Steroid therapy was ineffective and cyclosporin A (CsA) was discontinued due to its neurotoxicity with the development of leukoencephalopathy. However, the patient achieved a good hematological response after the use of mycophenolate mofetil (MMF, CellCept) with a dose of 1 g/day and prednisolone (15 mg/day). Prednisolone was tapered off over the next 3 weeks. The patient did not require any blood support 4 weeks after the use of MMF and has been hematologically stable for 4 months. To our knowledge, this is the first report of using MMF in treating MDS complicated by AIHA. MMF might be considered as a salvage therapy for patients with refractory anemia complicated by AIHA.",

keywords = "Autoimmune hemolytic anemia, Mycophenolate mofetil, Myelodysplastic syndrome",

author = "Lin, {J. T.} and Wang, {W. S.} and Yen, {C. C.} and Chiou, {T. J.} and Liu, {J. H.} and Hsiao, {L. T.} and Yang, {M. H.} and Chao, {T. C.} and Tai, {C. J.} and Chen, {P. M.}",

year = "2002",

month = dec,

doi = "10.1007/s00277-002-0539-3",

language = "English",

volume = "81",

pages = "723--726",

journal = "Annals of Hematology",

issn = "0939-5555",

publisher = "Springer Verlag",

number = "12",

}

TY - JOUR

T1 - Myelodysplastic syndrome complicated by autoimmune hemolytic anemia

T2 - Remission of refractory anemia following mycophenolate mofetil

AU - Lin, J. T.

AU - Wang, W. S.

AU - Yen, C. C.

AU - Chiou, T. J.

AU - Liu, J. H.

AU - Hsiao, L. T.

AU - Yang, M. H.

AU - Chao, T. C.

AU - Tai, C. J.

AU - Chen, P. M.

PY - 2002/12

Y1 - 2002/12

N2 - Autoimmune hemolytic anemia (AIHA) rarely occurs in myelodysplastic syndrome (MDS). A 36-year-old Asian female was diagnosed with MDS (refractory cytopenia with multilineage dysplasia, RCMD) and complicated by AIHA 7 months later. Secondary myelofibrosis developed at the same time. Steroid therapy was ineffective and cyclosporin A (CsA) was discontinued due to its neurotoxicity with the development of leukoencephalopathy. However, the patient achieved a good hematological response after the use of mycophenolate mofetil (MMF, CellCept) with a dose of 1 g/day and prednisolone (15 mg/day). Prednisolone was tapered off over the next 3 weeks. The patient did not require any blood support 4 weeks after the use of MMF and has been hematologically stable for 4 months. To our knowledge, this is the first report of using MMF in treating MDS complicated by AIHA. MMF might be considered as a salvage therapy for patients with refractory anemia complicated by AIHA.

AB - Autoimmune hemolytic anemia (AIHA) rarely occurs in myelodysplastic syndrome (MDS). A 36-year-old Asian female was diagnosed with MDS (refractory cytopenia with multilineage dysplasia, RCMD) and complicated by AIHA 7 months later. Secondary myelofibrosis developed at the same time. Steroid therapy was ineffective and cyclosporin A (CsA) was discontinued due to its neurotoxicity with the development of leukoencephalopathy. However, the patient achieved a good hematological response after the use of mycophenolate mofetil (MMF, CellCept) with a dose of 1 g/day and prednisolone (15 mg/day). Prednisolone was tapered off over the next 3 weeks. The patient did not require any blood support 4 weeks after the use of MMF and has been hematologically stable for 4 months. To our knowledge, this is the first report of using MMF in treating MDS complicated by AIHA. MMF might be considered as a salvage therapy for patients with refractory anemia complicated by AIHA.

KW - Autoimmune hemolytic anemia

KW - Mycophenolate mofetil

KW - Myelodysplastic syndrome

UR - http://www.scopus.com/inward/record.url?scp=0036963441&partnerID=8YFLogxK

U2 - 10.1007/s00277-002-0539-3

DO - 10.1007/s00277-002-0539-3

M3 - Article

C2 - 12483369

AN - SCOPUS:0036963441

SN - 0939-5555

VL - 81

SP - 723

EP - 726

JO - Annals of Hematology

JF - Annals of Hematology

IS - 12

ER -

Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: Remission of refractory anemia following mycophenolate mofetil

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this