Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced in Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

Po Jung Chen; Yi Da Kang; Chen Huan Lin; San Yuan Chen; Chia Hung Hsieh; You Yin Chen; Chun Wei Chiang; Wei Lee; Chung Y. Hsu; Lun De Liao; Chih Tai Fan; Meng Lin Li; Woei Cherng Shyu

doi:10.1002/adma.201502784

Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced in Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

Po Jung Chen, Yi Da Kang, Chen Huan Lin, San Yuan Chen^*, Chia Hung Hsieh, You Yin Chen, Chun Wei Chiang, Wei Lee, Chung Y. Hsu, Lun De Liao, Chih Tai Fan, Meng Lin Li, Woei Cherng Shyu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.

Original language	English
Pages (from-to)	6488-6495
Number of pages	8
Journal	Advanced Materials
Volume	27
Issue number	41
DOIs	https://doi.org/10.1002/adma.201502784
State	Published - 1 Nov 2015

Keywords

magnetic resonance imaging
mesenchymal stem cells
multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin
photoacoustic imaging
stroke therapy

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Chen, P. J., Kang, Y. D., Lin, C. H., Chen, S. Y., Hsieh, C. H., Chen, Y. Y., Chiang, C. W., Lee, W., Hsu, C. Y., Liao, L. D., Fan, C. T., Li, M. L., & Shyu, W. C. (2015). Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced in Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy. Advanced Materials, 27(41), 6488-6495. https://doi.org/10.1002/adma.201502784

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title = "Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced in Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy",

abstract = "A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.",

keywords = "magnetic resonance imaging, mesenchymal stem cells, multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin, photoacoustic imaging, stroke therapy",

author = "Chen, {Po Jung} and Kang, {Yi Da} and Lin, {Chen Huan} and Chen, {San Yuan} and Hsieh, {Chia Hung} and Chen, {You Yin} and Chiang, {Chun Wei} and Wei Lee and Hsu, {Chung Y.} and Liao, {Lun De} and Fan, {Chih Tai} and Li, {Meng Lin} and Shyu, {Woei Cherng}",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2015",

month = nov,

day = "1",

doi = "10.1002/adma.201502784",

language = "English",

volume = "27",

pages = "6488--6495",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

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Chen, PJ, Kang, YD, Lin, CH, Chen, SY, Hsieh, CH, Chen, YY, Chiang, CW, Lee, W, Hsu, CY, Liao, LD, Fan, CT, Li, ML & Shyu, WC 2015, 'Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced in Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy', Advanced Materials, vol. 27, no. 41, pp. 6488-6495. https://doi.org/10.1002/adma.201502784

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T1 - Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced in Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

AU - Chen, Po Jung

AU - Kang, Yi Da

AU - Lin, Chen Huan

AU - Chen, San Yuan

AU - Hsieh, Chia Hung

AU - Chen, You Yin

AU - Chiang, Chun Wei

AU - Lee, Wei

AU - Hsu, Chung Y.

AU - Liao, Lun De

AU - Fan, Chih Tai

AU - Li, Meng Lin

AU - Shyu, Woei Cherng

PY - 2015/11/1

Y1 - 2015/11/1

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AB - A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.

KW - magnetic resonance imaging

KW - mesenchymal stem cells

KW - multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin

KW - photoacoustic imaging

KW - stroke therapy

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SN - 0935-9648

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EP - 6495

JO - Advanced Materials

JF - Advanced Materials

IS - 41

ER -

Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced in Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

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