Multimodal Neural Evidence on the Corticostriatal Underpinning of Suicidality in Late-Life Depression

Robin Shao; Mengxia Gao; Chemin Lin; Chih-Mao Huang; Ho-Ling Liu; Cheng-Hong Toh; Changwei Wu; Yun-Fang Tsai; Di Qi; Shwu-Hua Lee; Tatia M.C. Lee

doi:10.1016/j.bpsc.2021.11.011

Multimodal Neural Evidence on the Corticostriatal Underpinning of Suicidality in Late-Life Depression

Robin Shao, Mengxia Gao, Chemin Lin, Chih-Mao Huang, Ho-Ling Liu, Cheng-Hong Toh, Changwei Wu, Yun-Fang Tsai, Di Qi, Shwu-Hua Lee, Tatia M.C. Lee

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Suicidality involves thoughts (ideations and plans) and actions related to self-inflicted death. To improve management and prevention of suicidality, it is essential to understand the key neural mechanisms underlying suicidal thoughts and actions. Following empirically informed neural framework, we hypothesized that suicidal thoughts would be primarily characterized by alterations in the default mode network (DMN) indicating disrupted self-related processing, whereas suicidal actions would be characterized by changes in the lateral prefrontal cortico-striatal circuitries implicating compromised action control.

Original language	English
Pages (from-to)	905-915
Number of pages	11
Journal	Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Volume	7
Issue number	9
Early online date	Nov 2021
DOIs	https://doi.org/10.1016/j.bpsc.2021.11.011
State	Published - 2022

Keywords

Caudate nucleus
Dynamic causal modeling
Late-life depression
Magnetic resonance imaging
Suicidality
Ventrolateral prefrontal cortex

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bpsc.2021.11.011

https://www.sciencedirect.com/science/article/pii/S2451902221003244

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title = "Multimodal Neural Evidence on the Corticostriatal Underpinning of Suicidality in Late-Life Depression",

abstract = "Suicidality involves thoughts (ideations and plans) and actions related to self-inflicted death. To improve management and prevention of suicidality, it is essential to understand the key neural mechanisms underlying suicidal thoughts and actions. Following empirically informed neural framework, we hypothesized that suicidal thoughts would be primarily characterized by alterations in the default mode network (DMN) indicating disrupted self-related processing, whereas suicidal actions would be characterized by changes in the lateral prefrontal cortico-striatal circuitries implicating compromised action control.",

keywords = "Caudate nucleus, Dynamic causal modeling, Late-life depression, Magnetic resonance imaging, Suicidality, Ventrolateral prefrontal cortex",

author = "Robin Shao and Mengxia Gao and Chemin Lin and Chih-Mao Huang and Ho-Ling Liu and Cheng-Hong Toh and Changwei Wu and Yun-Fang Tsai and Di Qi and Shwu-Hua Lee and Lee, {Tatia M.C.}",

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T1 - Multimodal Neural Evidence on the Corticostriatal Underpinning of Suicidality in Late-Life Depression

AU - Shao, Robin

AU - Gao, Mengxia

AU - Lin, Chemin

AU - Huang, Chih-Mao

AU - Liu, Ho-Ling

AU - Toh, Cheng-Hong

AU - Wu, Changwei

AU - Tsai, Yun-Fang

AU - Qi, Di

AU - Lee, Shwu-Hua

AU - Lee, Tatia M.C.

PY - 2022

Y1 - 2022

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AB - Suicidality involves thoughts (ideations and plans) and actions related to self-inflicted death. To improve management and prevention of suicidality, it is essential to understand the key neural mechanisms underlying suicidal thoughts and actions. Following empirically informed neural framework, we hypothesized that suicidal thoughts would be primarily characterized by alterations in the default mode network (DMN) indicating disrupted self-related processing, whereas suicidal actions would be characterized by changes in the lateral prefrontal cortico-striatal circuitries implicating compromised action control.

KW - Caudate nucleus

KW - Dynamic causal modeling

KW - Late-life depression

KW - Magnetic resonance imaging

KW - Suicidality

KW - Ventrolateral prefrontal cortex

U2 - 10.1016/j.bpsc.2021.11.011

DO - 10.1016/j.bpsc.2021.11.011

M3 - Article

C2 - 34861420

SN - 2451-9022

VL - 7

SP - 905

EP - 915

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

IS - 9

ER -

Multimodal Neural Evidence on the Corticostriatal Underpinning of Suicidality in Late-Life Depression

Abstract

Keywords

UN SDGs

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