Multifunctional polymer nanoparticles for dual drug release and cancer cell targeting

Yu Han Wen, Tsung Ying Lee, Ping Chuan Fu, Chun Liang Lo*, Yi Ting Chiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Multifunctional polymer nanoparticles have been developed for cancer treatment becausethey could be easily designed to target cancer cells and to enhance therapeutic efficacy accordingto cancer hallmarks. In this study, we synthesized a pH-sensitive polymer, poly(methacrylicacid-co-histidine/doxorubicin/biotin) (HBD) in which doxorubicin (DOX) was conjugated bya hydrazone bond to encapsulate an immunotherapy drug, imiquimod (IMQ), to form dualcancer-targeting and dual drug-loaded nanoparticles. At low pH, polymeric nanoparticles coulddisrupt and simultaneously release DOX and IMQ. Our experimental results show that thenanoparticles exhibited pH-dependent drug release behavior and had an ability to target cancer cellsvia biotin and protonated histidine.

Original languageEnglish
Article number213
Issue number6
StatePublished - 2017


  • Imiquimod
  • Multifunctional polymer
  • pH-sensitive
  • Polymeric nanoparticles


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