Monitoring of Vascular Response to Peri-Infarct Depolarization (PID) in Photothrombotic Stroke Animal Model

Yu Chieh Jill Kao, Bao Yu Hsieh

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Peri-infarct depolarization (PID) is abnormal transient depolarization waves slowly propagating in the cortex and confined in the ipsi-lesional cortex in accompanied with dramatic cerebral blood flow change. Ultrafast Doppler is a quantitative imaging method to investigate both CBF and CBV in a high spatiotemporal resolution and to measure the hemodynamic response of penetrating vessels in the cortex. In this study, the hemodynamics of cortical vessels during stroke-induced PID was monitored by the dynamic ultrafast Doppler under the animal model of photothrombotic stroke. The propagating PID-induced blood flow change (ΔCBV) initiated from the center of the stoke induction site and propagated outward in the right cortex. This study, for the first time, introduces a novel platform to demonstrate that dynamic ultrafast Doppler is feasible to monitor PID during acute stroke.

Original languageEnglish
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
PublisherIEEE Computer Society
Pages235-238
Number of pages4
ISBN (Electronic)9781728145969
DOIs
StatePublished - Oct 2019
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: 6 Oct 20199 Oct 2019

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
Country/TerritoryUnited Kingdom
CityGlasgow
Period6/10/199/10/19

Keywords

  • functional ultrasound (fUS)
  • peri-infarct depolarization (PID)
  • stroke
  • ultrafast Doppler

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