Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray

Kai Wang; Lu Gan; Eric Jeffery; Margit Gayle; Allen M. Gown; Marilyn Skelly; Peter S. Nelson; Weilap V. Ng; Michèl Schummer; Leroy Hood; John Mulligan

doi:10.1016/S0378-1119(99)00035-9

Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray

Kai Wang^*, Lu Gan, Eric Jeffery, Margit Gayle, Allen M. Gown, Marilyn Skelly, Peter S. Nelson, Weilap V. Ng, Michèl Schummer, Leroy Hood, John Mulligan

^*Corresponding author for this work

Department of Biotechnology and Laboratory Science in Medicine

Research output: Contribution to journal › Article › peer-review

288 Scopus citations

Abstract

The development of cancer is the result of a series of molecular changes occurring in the cell. These events lead to changes in the expression level of numerous genes that result in different phenotypic characteristics of tumors. In this report we describe the assembly and utilization of a 5766 member cDNA microarray to study the differences in gene expression between normal and neoplastic human ovarian tissues. Several genes that may have biological relevance in the process of ovarian carcinogenesis have been identified through this approach. Analyzing the results of microarray hybridizations may provides new leads for tumor diagnosis and intervention.

Original language	English
Pages (from-to)	101-108
Number of pages	8
Journal	Gene
Volume	229
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-1119(99)00035-9
State	Published - 18 Mar 1999

Keywords

Array
Carcinogenesis
Ovarian cancer
RT-PCR
Tumor marker

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0378-1119(99)00035-9

Cite this

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title = "Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray",

abstract = "The development of cancer is the result of a series of molecular changes occurring in the cell. These events lead to changes in the expression level of numerous genes that result in different phenotypic characteristics of tumors. In this report we describe the assembly and utilization of a 5766 member cDNA microarray to study the differences in gene expression between normal and neoplastic human ovarian tissues. Several genes that may have biological relevance in the process of ovarian carcinogenesis have been identified through this approach. Analyzing the results of microarray hybridizations may provides new leads for tumor diagnosis and intervention.",

keywords = "Array, Carcinogenesis, Ovarian cancer, RT-PCR, Tumor marker",

author = "Kai Wang and Lu Gan and Eric Jeffery and Margit Gayle and Gown, {Allen M.} and Marilyn Skelly and Nelson, {Peter S.} and Ng, {Weilap V.} and Mich{\`e}l Schummer and Leroy Hood and John Mulligan",

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T1 - Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray

AU - Wang, Kai

AU - Gan, Lu

AU - Jeffery, Eric

AU - Gayle, Margit

AU - Gown, Allen M.

AU - Skelly, Marilyn

AU - Nelson, Peter S.

AU - Ng, Weilap V.

AU - Schummer, Michèl

AU - Hood, Leroy

AU - Mulligan, John

PY - 1999/3/18

Y1 - 1999/3/18

N2 - The development of cancer is the result of a series of molecular changes occurring in the cell. These events lead to changes in the expression level of numerous genes that result in different phenotypic characteristics of tumors. In this report we describe the assembly and utilization of a 5766 member cDNA microarray to study the differences in gene expression between normal and neoplastic human ovarian tissues. Several genes that may have biological relevance in the process of ovarian carcinogenesis have been identified through this approach. Analyzing the results of microarray hybridizations may provides new leads for tumor diagnosis and intervention.

AB - The development of cancer is the result of a series of molecular changes occurring in the cell. These events lead to changes in the expression level of numerous genes that result in different phenotypic characteristics of tumors. In this report we describe the assembly and utilization of a 5766 member cDNA microarray to study the differences in gene expression between normal and neoplastic human ovarian tissues. Several genes that may have biological relevance in the process of ovarian carcinogenesis have been identified through this approach. Analyzing the results of microarray hybridizations may provides new leads for tumor diagnosis and intervention.

KW - Array

KW - Carcinogenesis

KW - Ovarian cancer

KW - RT-PCR

KW - Tumor marker

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U2 - 10.1016/S0378-1119(99)00035-9

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AN - SCOPUS:0033580456

SN - 0378-1119

VL - 229

SP - 101

EP - 108

JO - Gene

JF - Gene

IS - 1-2

ER -

Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray

Abstract

Keywords

UN SDGs

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