Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray

Kai Wang*, Lu Gan, Eric Jeffery, Margit Gayle, Allen M. Gown, Marilyn Skelly, Peter S. Nelson, Weilap V. Ng, Michèl Schummer, Leroy Hood, John Mulligan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

287 Scopus citations

Abstract

The development of cancer is the result of a series of molecular changes occurring in the cell. These events lead to changes in the expression level of numerous genes that result in different phenotypic characteristics of tumors. In this report we describe the assembly and utilization of a 5766 member cDNA microarray to study the differences in gene expression between normal and neoplastic human ovarian tissues. Several genes that may have biological relevance in the process of ovarian carcinogenesis have been identified through this approach. Analyzing the results of microarray hybridizations may provides new leads for tumor diagnosis and intervention.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalGene
Volume229
Issue number1-2
DOIs
StatePublished - 18 Mar 1999

Keywords

  • Array
  • Carcinogenesis
  • Ovarian cancer
  • RT-PCR
  • Tumor marker

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