Modulating motor cortical oscillation with coordinated reset multifocal transcranial magnetic stimulation

Kai Hsiang Stanley Chen, Tzu Kang Hung, Rupesh Kumar Chikara, Yu Ting Kuo, Yi Ping Liu, Yan Siou Dong, Yih Ru Wu, Li Wei Ko, Ying Zu Huang, Robert Chen

Research output: Contribution to journalArticlepeer-review

Abstract

According to the theory of coordinated reset (CR) stimulation, multifocal bursts of stimuli delivered in a random order with a specific interval may reduce the resonance power of the oscillatory generator in the epicenter. We develop a noninvasive coordinated multifocal burst stimulation (COMBS) with three repetitive transcranial stimulation machines based on CR theory to modulate the target frequency in the primary motor cortex and to assess its effect on motor cortical excitability in separate experiments. Electroencephalography and electromyography were recorded in 16 healthy participants during a finger-tapping task, both before and after the intervention. The resting oscillatory power at the targeted frequency was not changed by COMBS. α-Band power was increased in both preparation and movement stages and the low β-band power was increased in the movement stage of the finger tapping task. The extent of low β-band event-related desynchronization was reduced by COMBS. There were no changes in reaction time, but there was a trend for a reduced error rate after COMBS. In another 14 healthy participants, there were no significant changes in cortical excitability before and after COMBS measured by rest motor threshold, short interval intracortical inhibition, short interval intracortical facilitation, and cortical silent period. The result indicates that COMBS may modify the cortical oscillatory power and its perturbation within specific movement stage.NEW & NOTEWORTHY This is the first study, to our knowledge, to apply coordinated reset (CR) neuromodulation to the motor cortex with three repetitive transcranial magnetic stimulation (rTMS) stimulators to assess its effect on cortical oscillation. The results revealed enhancement of α-band power specifically in preparation and movement stages and low β-band power in the movement stage of a motor task. It postulated that CR stimulation may modify the motor cortical oscillation in the specific movement stages.

Original languageEnglish
Pages (from-to)1061-1071
Number of pages11
JournalJournal of Neurophysiology
Volume129
Issue number5
DOIs
StatePublished - 1 May 2023

Keywords

  • coordinated reset
  • event-related desynchronization
  • low beta oscillation
  • motor cortical excitability
  • repetitive transcranial magnetic stimulation (rTMS)

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