Mixed micelle systems formed from critical micelle concentration and temperature-sensitive diblock copolymers for doxorubicin delivery

Chun Liang Lo, Sheng Jie Lin, Hsieh Chih Tsai, Wei Hsiang Chan, Cheng Hung Tsai, Chien Hsin D. Cheng, Ging Ho Hsiue*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Mixed micelles formed by critical micelle concentration (Cmc) character's diblock copolymer, and temperature-sensitive character's diblock copolymer were studied for their capabilities in improving stability with and without drug. Experimental results showed that this type of mixed micellar systems possessed complementary effects in adjusting external temperature shift (storage vs. body temperature) and concentration change (dilution after intravenous injection). Therefore, they provided excellent stability as drug carriers. Further results obtained from physicochemical property and drug release kinetics studies demonstrated such systems could also be applied to physiological conditions, in compliance with varied pH environments. We concluded that the newly developed mixed micelles can serve as a potential injectable drug delivery system for anticancer drugs, such as doxorubicin and many others.

Original languageEnglish
Pages (from-to)3961-3970
Number of pages10
JournalBiomaterials
Volume30
Issue number23-24
DOIs
StatePublished - Aug 2009

Keywords

  • Cmc diblock copolymer
  • Drug delivery
  • Micellar stability
  • Mixed micelle
  • Temperature-sensitive diblock copolymer

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