miR-21 microRNA expression in human gastric carcinomas and its clinical association

Shih Hsuan Chan, Chew Wun Wu, Anna F.Y. Li, Chin Wen Chi, Wen Chang Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

201 Scopus citations


Background: MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that have been shown to be aberrantly expressed in many human carcinomas. Of these miRNAs, miR-21 appears to be important in tumorigenesis given its up-regulation in almost all types of human cancer examined. However, its association with the clinicopathological features of human gastric cancer has yet to be addressed. Patients and Methods: Cancer tissues and corresponding normal tissues from 37 patients with gastric cancer were examined for the expression level of miR-21 using quantitative PCR and the clinical relevance of miR-21 was statistically analyzed. Results: miR-21 was overexpressed in 92% (34/37) of the gastric cancer samples examined. However, the patients with higher miR-21 expression did not have a worse prognosis. Conclusion: miR-21 could serve as an efficient diagnostic marker for gastric cancer, but does not affect the clinical prognosis of gastric cancer patients.

Original languageEnglish
Pages (from-to)907-911
Number of pages5
JournalAnticancer Research
Issue number2 A
StatePublished - Mar 2008


  • Gastric cancer
  • MicroRNAs (miRNAs)
  • miR-21
  • Prognosis


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