Abstract
Background: MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that have been shown to be aberrantly expressed in many human carcinomas. Of these miRNAs, miR-21 appears to be important in tumorigenesis given its up-regulation in almost all types of human cancer examined. However, its association with the clinicopathological features of human gastric cancer has yet to be addressed. Patients and Methods: Cancer tissues and corresponding normal tissues from 37 patients with gastric cancer were examined for the expression level of miR-21 using quantitative PCR and the clinical relevance of miR-21 was statistically analyzed. Results: miR-21 was overexpressed in 92% (34/37) of the gastric cancer samples examined. However, the patients with higher miR-21 expression did not have a worse prognosis. Conclusion: miR-21 could serve as an efficient diagnostic marker for gastric cancer, but does not affect the clinical prognosis of gastric cancer patients.
| Original language | English |
|---|---|
| Pages (from-to) | 907-911 |
| Number of pages | 5 |
| Journal | Anticancer Research |
| Volume | 28 |
| Issue number | 2 A |
| State | Published - Mar 2008 |
Keywords
- Gastric cancer
- MicroRNAs (miRNAs)
- miR-21
- Prognosis
