Miniaturized video-rate epi-third-harmonic-generation fiber-microscope

Shih Hsuan Chia; Che Hang Yu; Chih Han Lin; Nai Chia Cheng; Tzu Ming Liu; Ming Che Chan; I. Hsiu Chen; Chi Kuang Sun

doi:10.1364/OE.18.017382

Miniaturized video-rate epi-third-harmonic-generation fiber-microscope

Shih Hsuan Chia, Che Hang Yu, Chih Han Lin, Nai Chia Cheng, Tzu Ming Liu, Ming Che Chan, I. Hsiu Chen, Chi Kuang Sun^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

With a micro-electro-mechanical system (MEMS) mirror, we successfully developed a miniaturized epi-third-harmonic-generation (epi-THG) fiber-microscope with a video frame rate (31Hz), which was designed for in vivo optical biopsy of human skin. With a large-mode-area (LMA) photonic crystal fiber (PCF) and a regular microscopic objective, the nonlinear distortion of the ultrafast pulses delivery could be much reduced while still achieving a 0.4μm lateral resolution for epi-THG signals. In vivo real time virtual biopsy of the Asian skin with a video rate (31Hz) and a sub-micron resolution was obtained. The result indicates that this miniaturized system was compact enough for the least invasive hand-held clinical use.

Original language	English
Pages (from-to)	17382-17391
Number of pages	10
Journal	Optics Express
Volume	18
Issue number	16
DOIs	https://doi.org/10.1364/OE.18.017382
State	Published - 2 Aug 2010

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abstract = "With a micro-electro-mechanical system (MEMS) mirror, we successfully developed a miniaturized epi-third-harmonic-generation (epi-THG) fiber-microscope with a video frame rate (31Hz), which was designed for in vivo optical biopsy of human skin. With a large-mode-area (LMA) photonic crystal fiber (PCF) and a regular microscopic objective, the nonlinear distortion of the ultrafast pulses delivery could be much reduced while still achieving a 0.4μm lateral resolution for epi-THG signals. In vivo real time virtual biopsy of the Asian skin with a video rate (31Hz) and a sub-micron resolution was obtained. The result indicates that this miniaturized system was compact enough for the least invasive hand-held clinical use.",

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AU - Yu, Che Hang

AU - Lin, Chih Han

AU - Cheng, Nai Chia

AU - Liu, Tzu Ming

AU - Chan, Ming Che

AU - Chen, I. Hsiu

AU - Sun, Chi Kuang

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AB - With a micro-electro-mechanical system (MEMS) mirror, we successfully developed a miniaturized epi-third-harmonic-generation (epi-THG) fiber-microscope with a video frame rate (31Hz), which was designed for in vivo optical biopsy of human skin. With a large-mode-area (LMA) photonic crystal fiber (PCF) and a regular microscopic objective, the nonlinear distortion of the ultrafast pulses delivery could be much reduced while still achieving a 0.4μm lateral resolution for epi-THG signals. In vivo real time virtual biopsy of the Asian skin with a video rate (31Hz) and a sub-micron resolution was obtained. The result indicates that this miniaturized system was compact enough for the least invasive hand-held clinical use.

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Miniaturized video-rate epi-third-harmonic-generation fiber-microscope

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