Miniaturized Intracerebral Potential Recorder for Long-Term Local Field Potential of Deep Brain Signals

Yi Hui Wu; Yi Huan Ou-Yang; Chiung-Chu Chen; Chen Yi Lee; Chung-Yu Wu; Ming-Dou Ker

doi:10.1109/EMBC44109.2020.9175384

Miniaturized Intracerebral Potential Recorder for Long-Term Local Field Potential of Deep Brain Signals

Yi Hui Wu^*, Yi Huan Ou-Yang, Chiung-Chu Chen, Chen Yi Lee, Chung-Yu Wu, Ming-Dou Ker

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

A miniaturized intracerebral potential recorder for long-term local field potential (LFP) of deep brain signals is proposed. LFP can be recorded by deep brain electrodes. The abnormal beta-band oscillation of LFP in subthalamic nucleus and internal globus pallidus in patients with Parkinson's disease (PD) are associated with the severity of the symptoms. The LFP signal from patients who have been implanted with deep brain electrode can be monitored by our system for at least 24 hours in real time. Graphical user interface has also been developed for use by medical personnel. Imitation experiments and in vivo experiments were performed to successfully verify that our system can measure LFP signals. With 24-hour intracerebral signals, researchers can analyze what is happened in the brain in daily life. In the future, more effective PD treatment can be developed, such as intelligent closed-loop deep brain stimulation.

Original language	English
Title of host publication	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publication	Enabling Innovative Technologies for Global Healthcare, EMBC 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	5188-5191
Number of pages	4
ISBN (Electronic)	9781728119908
ISBN (Print)	978-1-7281-1991-5
DOIs	https://doi.org/10.1109/EMBC44109.2020.9175384
State	Published - 20 Jul 2020
Event	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Canada Duration: 20 Jul 2020 → 24 Jul 2020

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2020-July
ISSN (Print)	1557-170X

Conference

Conference	42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
Country/Territory	Canada
City	Montreal
Period	20/07/20 → 24/07/20

Keywords

beta-band oscillation
deep brain signals
graphical user interface
local field potential
Parkinson's disease

Access to Document

10.1109/EMBC44109.2020.9175384

Cite this

Wu, Y. H., Ou-Yang, Y. H., Chen, C.-C., Lee, C. Y., Wu, C.-Y., & Ker, M.-D. (2020). Miniaturized Intracerebral Potential Recorder for Long-Term Local Field Potential of Deep Brain Signals. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020 (pp. 5188-5191). Article 9175384 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC44109.2020.9175384

Wu, Yi Hui ; Ou-Yang, Yi Huan ; Chen, Chiung-Chu et al. / Miniaturized Intracerebral Potential Recorder for Long-Term Local Field Potential of Deep Brain Signals. 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. pp. 5188-5191 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Miniaturized Intracerebral Potential Recorder for Long-Term Local Field Potential of Deep Brain Signals",

abstract = "A miniaturized intracerebral potential recorder for long-term local field potential (LFP) of deep brain signals is proposed. LFP can be recorded by deep brain electrodes. The abnormal beta-band oscillation of LFP in subthalamic nucleus and internal globus pallidus in patients with Parkinson's disease (PD) are associated with the severity of the symptoms. The LFP signal from patients who have been implanted with deep brain electrode can be monitored by our system for at least 24 hours in real time. Graphical user interface has also been developed for use by medical personnel. Imitation experiments and in vivo experiments were performed to successfully verify that our system can measure LFP signals. With 24-hour intracerebral signals, researchers can analyze what is happened in the brain in daily life. In the future, more effective PD treatment can be developed, such as intelligent closed-loop deep brain stimulation.",

keywords = "beta-band oscillation, deep brain signals, graphical user interface, local field potential, Parkinson's disease",

author = "Wu, {Yi Hui} and Ou-Yang, {Yi Huan} and Chiung-Chu Chen and Lee, {Chen Yi} and Chung-Yu Wu and Ming-Dou Ker",

note = "Publisher Copyright: {\textcopyright} 2020 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 ; Conference date: 20-07-2020 Through 24-07-2020",

year = "2020",

month = jul,

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doi = "10.1109/EMBC44109.2020.9175384",

language = "English",

isbn = "978-1-7281-1991-5",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

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Wu, YH, Ou-Yang, YH, Chen, C-C, Lee, CY, Wu, C-Y & Ker, M-D 2020, Miniaturized Intracerebral Potential Recorder for Long-Term Local Field Potential of Deep Brain Signals. in 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020., 9175384, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2020-July, Institute of Electrical and Electronics Engineers Inc., pp. 5188-5191, 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020, Montreal, Canada, 20/07/20. https://doi.org/10.1109/EMBC44109.2020.9175384

Miniaturized Intracerebral Potential Recorder for Long-Term Local Field Potential of Deep Brain Signals. / Wu, Yi Hui; Ou-Yang, Yi Huan; Chen, Chiung-Chu et al.
42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 5188-5191 9175384 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Lee, Chen Yi

AU - Wu, Chung-Yu

AU - Ker, Ming-Dou

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AB - A miniaturized intracerebral potential recorder for long-term local field potential (LFP) of deep brain signals is proposed. LFP can be recorded by deep brain electrodes. The abnormal beta-band oscillation of LFP in subthalamic nucleus and internal globus pallidus in patients with Parkinson's disease (PD) are associated with the severity of the symptoms. The LFP signal from patients who have been implanted with deep brain electrode can be monitored by our system for at least 24 hours in real time. Graphical user interface has also been developed for use by medical personnel. Imitation experiments and in vivo experiments were performed to successfully verify that our system can measure LFP signals. With 24-hour intracerebral signals, researchers can analyze what is happened in the brain in daily life. In the future, more effective PD treatment can be developed, such as intelligent closed-loop deep brain stimulation.

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ER -

Wu YH, Ou-Yang YH, Chen CC, Lee CY, Wu CY, Ker MD. Miniaturized Intracerebral Potential Recorder for Long-Term Local Field Potential of Deep Brain Signals. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc. 2020. p. 5188-5191. 9175384. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC44109.2020.9175384

Miniaturized Intracerebral Potential Recorder for Long-Term Local Field Potential of Deep Brain Signals

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