Miniaturized cortex cooling device and system for hypothermia therapy application on freely moving rat

Chih Wei Chang*, Kuan Chou Hou, Lei Chun Chou, Jin-Chern Chiou, Jeng-Ren Duann, Yun Wen Tsai

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


This paper presents a miniaturized brain cortex cooling device and system using thermoelectric (TE) cooler for hypothermia therapy application on freely moving rat. Two type of cooling electrodes including planar and micro-needle structures are fabricated and studied by EEG recording. Comparing to prior arts, our approach can be applied under freely moving behavior. The cooling temperature is designed as 2°C to avoid permanent injury in brain. Packaged planar or needle electrode with TE cooler consumes only 2×2mm2. EEG recording electrodes and thermocouple are implanted for observation as well. Simulation result shows that TE-cooler with needle type electrode behaves deeper effective cooling depth and faster cooling response in rodent cortex range (∼2mm deep). Long term EEG monitoring on freely moving rat also presents no extra side effects with continuously cooling.

Original languageEnglish
Title of host publicationIEEE SENSORS 2012 - Proceedings
StatePublished - 1 Dec 2012
Event11th IEEE SENSORS 2012 Conference - Taipei, Taiwan
Duration: 28 Oct 201231 Oct 2012

Publication series

NameProceedings of IEEE Sensors


Conference11th IEEE SENSORS 2012 Conference


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