Microwave-assisted efficient conjugation of nanodiamond and paclitaxel

Yi Han Hsieh; Kuang Kai Liu; Rohidas S. Sulake; Jui-I Chao; Chinpiao Chen

doi:10.1016/j.bmcl.2015.03.089

Microwave-assisted efficient conjugation of nanodiamond and paclitaxel

Yi Han Hsieh, Kuang Kai Liu, Rohidas S. Sulake, Jui-I Chao^*, Chinpiao Chen

^*Corresponding author for this work

Institute of Molecular Medicine and Bioengineering

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond.

Original language	English
Pages (from-to)	2074-2077
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2015.03.089
State	Published - 15 Jun 2015

Keywords

Deaggregation
Lung cancer
Microwave irradiating
Nanodiamond
Paclitaxel

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2015.03.089

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title = "Microwave-assisted efficient conjugation of nanodiamond and paclitaxel",

abstract = "Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond.",

keywords = "Deaggregation, Lung cancer, Microwave irradiating, Nanodiamond, Paclitaxel",

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T1 - Microwave-assisted efficient conjugation of nanodiamond and paclitaxel

AU - Hsieh, Yi Han

AU - Liu, Kuang Kai

AU - Sulake, Rohidas S.

AU - Chao, Jui-I

AU - Chen, Chinpiao

PY - 2015/6/15

Y1 - 2015/6/15

N2 - Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond.

AB - Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond.

KW - Deaggregation

KW - Lung cancer

KW - Microwave irradiating

KW - Nanodiamond

KW - Paclitaxel

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M3 - Article

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SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Microwave-assisted efficient conjugation of nanodiamond and paclitaxel

Abstract

Keywords

UN SDGs

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