Microfluidics and nanomaterial-based technologies for circulating tumor cell isolation and detection

Sheng Jen Cheng; Kuan Yu Hsieh; Shiue Luen Chen; Chong You Chen; Chien Yu Huang; Hung I. Tsou; Priyank V. Kumar; Jason Chia Hsun Hsieh; Guan-Yu Chen

doi:10.3390/s20071875

Microfluidics and nanomaterial-based technologies for circulating tumor cell isolation and detection

Sheng Jen Cheng, Kuan Yu Hsieh, Shiue Luen Chen, Chong You Chen, Chien Yu Huang, Hung I. Tsou, Priyank V. Kumar, Jason Chia Hsun Hsieh^*, Guan-Yu Chen

^*Corresponding author for this work

Institute of Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Cancer has been one of the leading causes of death globally, with metastases and recurrences contributing to this result. The detection of circulating tumor cells (CTCs), which have been implicated as a major population of cells that is responsible for seeding and migration of tumor sites, could contribute to early detection of metastasis and recurrences, consequently increasing the chances of cure. This review article focuses on the current progress in microfluidics technology in CTCs diagnostics, extending to the use of nanomaterials and surface modification techniques for diagnostic applications, with an emphasis on the importance of integrating microchannels, nanomaterials, and surface modification techniques in the isolating and detecting of CTCs.

Original language	English
Article number	1875
Pages (from-to)	1-21
Number of pages	21
Journal	Sensors (Switzerland)
Volume	20
Issue number	7
DOIs	https://doi.org/10.3390/s20071875
State	Published - 1 Apr 2020

Keywords

Circulating tumor cells
Graphene oxide
Liquid biopsy
Microfluidic
Surface modification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/s20071875

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title = "Microfluidics and nanomaterial-based technologies for circulating tumor cell isolation and detection",

abstract = "Cancer has been one of the leading causes of death globally, with metastases and recurrences contributing to this result. The detection of circulating tumor cells (CTCs), which have been implicated as a major population of cells that is responsible for seeding and migration of tumor sites, could contribute to early detection of metastasis and recurrences, consequently increasing the chances of cure. This review article focuses on the current progress in microfluidics technology in CTCs diagnostics, extending to the use of nanomaterials and surface modification techniques for diagnostic applications, with an emphasis on the importance of integrating microchannels, nanomaterials, and surface modification techniques in the isolating and detecting of CTCs.",

keywords = "Circulating tumor cells, Graphene oxide, Liquid biopsy, Microfluidic, Surface modification",

author = "Cheng, {Sheng Jen} and Hsieh, {Kuan Yu} and Chen, {Shiue Luen} and Chen, {Chong You} and Huang, {Chien Yu} and Tsou, {Hung I.} and Kumar, {Priyank V.} and Hsieh, {Jason Chia Hsun} and Guan-Yu Chen",

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year = "2020",

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doi = "10.3390/s20071875",

language = "English",

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AU - Cheng, Sheng Jen

AU - Hsieh, Kuan Yu

AU - Chen, Shiue Luen

AU - Chen, Chong You

AU - Huang, Chien Yu

AU - Tsou, Hung I.

AU - Kumar, Priyank V.

AU - Hsieh, Jason Chia Hsun

AU - Chen, Guan-Yu

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Cancer has been one of the leading causes of death globally, with metastases and recurrences contributing to this result. The detection of circulating tumor cells (CTCs), which have been implicated as a major population of cells that is responsible for seeding and migration of tumor sites, could contribute to early detection of metastasis and recurrences, consequently increasing the chances of cure. This review article focuses on the current progress in microfluidics technology in CTCs diagnostics, extending to the use of nanomaterials and surface modification techniques for diagnostic applications, with an emphasis on the importance of integrating microchannels, nanomaterials, and surface modification techniques in the isolating and detecting of CTCs.

AB - Cancer has been one of the leading causes of death globally, with metastases and recurrences contributing to this result. The detection of circulating tumor cells (CTCs), which have been implicated as a major population of cells that is responsible for seeding and migration of tumor sites, could contribute to early detection of metastasis and recurrences, consequently increasing the chances of cure. This review article focuses on the current progress in microfluidics technology in CTCs diagnostics, extending to the use of nanomaterials and surface modification techniques for diagnostic applications, with an emphasis on the importance of integrating microchannels, nanomaterials, and surface modification techniques in the isolating and detecting of CTCs.

KW - Circulating tumor cells

KW - Graphene oxide

KW - Liquid biopsy

KW - Microfluidic

KW - Surface modification

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ER -

Microfluidics and nanomaterial-based technologies for circulating tumor cell isolation and detection

Abstract

Keywords

UN SDGs

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