MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma

Wei Chen Yen, Kai Ping Chang, Cheng Yi Chen, Yenlin Huang, Ting Wen Chen, Hsing Wen Cheng, Jui Shan Yi, Chun Chia Cheng, Chih Ching Wu, Chun I. Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Oral squamous cell carcinoma (OSCC) is the predominant histological type of the head and neck squamous cell carcinoma (HNSCC). By comparing the differentially expressed genes (DEGs) in OSCC-TCGA patients with copy number variations (CNVs) that we identify in OSCC-OncoScan dataset, we herein identified 37 dysregulated candidate genes. Among these potential candidate genes, 26 have been previously reported as dysregulated proteins or genes in HNSCC. Among 11 novel candidates, the overall survival analysis revealed that melanotransferrin (MFI2) is the most significant prognostic molecular in OSCC-TCGA patients. Another independent Taiwanese cohort confirmed that higher MFI2 transcript levels were significantly associated with poor prognosis. Mechanistically, we found that knockdown of MFI2 reduced cell viability, migration and invasion via modulating EGF/FAK signaling in OSCC cells. Collectively, our results support a mechanistic understanding of a novel role for MFI2 in promoting cell invasiveness in OSCC.

Original languageEnglish
Article number112
JournalCancer Cell International
Volume23
Issue number1
DOIs
StatePublished - Dec 2023

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