Metasurface-Based Abrupt Autofocusing Beam for Biomedical Applications

Yuan Luo; Ming Lun Tseng; Sunil Vyas; Hsin Yu Kuo; Cheng Hung Chu; Mu Ku Chen; Hsiang Chieh Lee; Wen Pin Chen; Vin Cent Su; Xu Shi; Hiroaki Misawa; Din Ping Tsai; Pan Chyr Yang

doi:10.1002/smtd.202101228

Metasurface-Based Abrupt Autofocusing Beam for Biomedical Applications

Yuan Luo^*, Ming Lun Tseng, Sunil Vyas, Hsin Yu Kuo, Cheng Hung Chu, Mu Ku Chen, Hsiang Chieh Lee, Wen Pin Chen, Vin Cent Su, Xu Shi, Hiroaki Misawa, Din Ping Tsai, Pan Chyr Yang

^*Corresponding author for this work

Institute of Electronics

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Manipulation and precise delivery of optical energies in the regions of interest within specimens require different strategies. Hence, proper control of input beam parameters is a prerequisite. One of the prominent methods is metasurface optics, capable of crafting properties of light at nanoscales. Here, the generation of an abrupt autofocusing (AAF) beam by a nanophotonic metasurface for biomedical applications is demonstrated. Fluorescence guided laser microprofiling of mouse cardiac samples is experimentally investigated, using the AAF beam to deliver optical energy selectively to specific locations. In addition, photocoagulation of ex vivo swine skin tissue is performed and observed through optical coherence tomography. The results show great potentials for integrating metasurface optics to realize miniature laser surgery instruments for wide applications in biomedicine.

Original language	English
Journal	Small Methods
DOIs	https://doi.org/10.1002/smtd.202101228
State	Accepted/In press - 2022

Keywords

abrupt autofocusing beam
laser surgery
metasurfaces

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10.1002/smtd.202101228

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title = "Metasurface-Based Abrupt Autofocusing Beam for Biomedical Applications",

abstract = "Manipulation and precise delivery of optical energies in the regions of interest within specimens require different strategies. Hence, proper control of input beam parameters is a prerequisite. One of the prominent methods is metasurface optics, capable of crafting properties of light at nanoscales. Here, the generation of an abrupt autofocusing (AAF) beam by a nanophotonic metasurface for biomedical applications is demonstrated. Fluorescence guided laser microprofiling of mouse cardiac samples is experimentally investigated, using the AAF beam to deliver optical energy selectively to specific locations. In addition, photocoagulation of ex vivo swine skin tissue is performed and observed through optical coherence tomography. The results show great potentials for integrating metasurface optics to realize miniature laser surgery instruments for wide applications in biomedicine.",

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author = "Yuan Luo and Tseng, {Ming Lun} and Sunil Vyas and Kuo, {Hsin Yu} and Chu, {Cheng Hung} and Chen, {Mu Ku} and Lee, {Hsiang Chieh} and Chen, {Wen Pin} and Su, {Vin Cent} and Xu Shi and Hiroaki Misawa and Tsai, {Din Ping} and Yang, {Pan Chyr}",

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year = "2022",

doi = "10.1002/smtd.202101228",

language = "English",

journal = "Small Methods",

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publisher = "John Wiley and Sons Ltd",

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AU - Luo, Yuan

AU - Tseng, Ming Lun

AU - Vyas, Sunil

AU - Kuo, Hsin Yu

AU - Chu, Cheng Hung

AU - Chen, Mu Ku

AU - Lee, Hsiang Chieh

AU - Chen, Wen Pin

AU - Su, Vin Cent

AU - Shi, Xu

AU - Misawa, Hiroaki

AU - Tsai, Din Ping

AU - Yang, Pan Chyr

PY - 2022

Y1 - 2022

N2 - Manipulation and precise delivery of optical energies in the regions of interest within specimens require different strategies. Hence, proper control of input beam parameters is a prerequisite. One of the prominent methods is metasurface optics, capable of crafting properties of light at nanoscales. Here, the generation of an abrupt autofocusing (AAF) beam by a nanophotonic metasurface for biomedical applications is demonstrated. Fluorescence guided laser microprofiling of mouse cardiac samples is experimentally investigated, using the AAF beam to deliver optical energy selectively to specific locations. In addition, photocoagulation of ex vivo swine skin tissue is performed and observed through optical coherence tomography. The results show great potentials for integrating metasurface optics to realize miniature laser surgery instruments for wide applications in biomedicine.

AB - Manipulation and precise delivery of optical energies in the regions of interest within specimens require different strategies. Hence, proper control of input beam parameters is a prerequisite. One of the prominent methods is metasurface optics, capable of crafting properties of light at nanoscales. Here, the generation of an abrupt autofocusing (AAF) beam by a nanophotonic metasurface for biomedical applications is demonstrated. Fluorescence guided laser microprofiling of mouse cardiac samples is experimentally investigated, using the AAF beam to deliver optical energy selectively to specific locations. In addition, photocoagulation of ex vivo swine skin tissue is performed and observed through optical coherence tomography. The results show great potentials for integrating metasurface optics to realize miniature laser surgery instruments for wide applications in biomedicine.

KW - abrupt autofocusing beam

KW - laser surgery

KW - metasurfaces

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U2 - 10.1002/smtd.202101228

DO - 10.1002/smtd.202101228

M3 - Article

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SN - 2366-9608

JO - Small Methods

JF - Small Methods

ER -

Metasurface-Based Abrupt Autofocusing Beam for Biomedical Applications

Abstract

Keywords

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