Metallodendrimers and dendrimer nanocomposites

Yi Hsuan Tang, Adela Ya Ting Huang, Po Yu Chen, Hui Ting Chen, Chai Lin Kao*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Dendrimers are polymeric compounds with highly branched structures and functionally tunable peripheral groups. Because of their low polydispersity, high degree of molecular uniformity, and precisely controlled structure, dendrimers are excellent models for demonstrating a variety of biological activities. With the attachment of metals ions and/or metals, metallodendrimers or dendrimer nanocomposites, respectively, provide diverse characters for a variety of applications. Functionalization with additional moieties, such as targeted peptides or chromophores, yields metallodendrimers that can find powerful applications and exceed the capabilities of nondendritic molecules or small molecule analogs. This review introduces the background of metallodendrimers and dendrimer nanocomposites. Biomedical applications of metallodendrimers and dendrimer nanocomposites will be discussed, including biomimetic catalysts, imaging contrast agents (especially for MRI imaging), or biomedical sensors and therapeutic agents.

Original languageEnglish
Pages (from-to)2308-2330
Number of pages23
JournalCurrent Pharmaceutical Design
Volume17
Issue number22
DOIs
StatePublished - Jul 2011

Keywords

  • Biomimetic catalysts
  • Biosensors
  • Contrast agents
  • Dendrimer nanocomposites
  • Metallodendrimers
  • Therapeutic agents

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