Mechanism of neuroprotective function of taurine

Jang Yen Wu*, Heng Wu, Ying Jin, Jianning Wei, Di Sha, Howard Prentice, Hsin Hsueh Lee, Chun Hua Lin, Yi Hsuan Lee, Ling Ling Yang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

54 Scopus citations

Abstract

Taurine has potent protective function against glutamate-induced neuronal injury presumably through its function in regulation of intracellular free calcium level, [Ca2+]i. In this communication, we report that taurine exerts its protective function through one or more of the following mechanisms: 1. Inhibition of glutamate-induced calcium influx through L-, N- and P/Q-type voltage-gated calcium channels and NMDA receptor calcium channel; 2. Attenuation of glutamate-induced membrane depolarization; 3. Prevention of glutamate-induced apoptosis via preventing glutamate-mediated down-regulation of Bcl-2; 4. Prevention of cleavage of Bcl-2 by calpain. This action of taurine is due to its inhibition on glutamate induced calpain activation. Based on these observations, we propose that taurine protects neurons against glutamate-induced neurotoxicity in part, by preventing glutamate-induced membrane depolarization, elevation of [Ca2+]i, activation of calpain, reduction of Bcl-2 and apoptosis.

Original languageEnglish
Title of host publicationTaurine 7
EditorsJunichi Azuma, Ito Takashi, Stephen Schaffer
Pages169-179
Number of pages11
DOIs
StatePublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
Volume643
ISSN (Print)0065-2598

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