TY - GEN
T1 - Measurement of both viscous and elastic constants of a red blood cell in a microchannel
AU - Kirimoto, Atsushi
AU - Ito, Hiroaki
AU - Tsai, Chia-Hung
AU - Kaneko, Makoto
PY - 2018/4/24
Y1 - 2018/4/24
N2 - In this paper, we propose a novel measurement of both viscous and elastic constants of a red blood cell (RBC) in a microfluidic channel. Although simultaneous measurement of absolute values of RBC viscosity and elasticity has been difficult in a microfluidic channel so far, here we achieved it using precise feedback cell manipulation inside the microchannel. According to deformed shape and theoretically estimated shear force, we first obtained Young's modulus, consistent with that obtained in the previous methods with force sensors. In addition, conducting 'Loading examination' for the same RBC in the downstream of the microchannel, we succeeded in the estimation of absolute values of viscous and elastic constants of a RBC.
AB - In this paper, we propose a novel measurement of both viscous and elastic constants of a red blood cell (RBC) in a microfluidic channel. Although simultaneous measurement of absolute values of RBC viscosity and elasticity has been difficult in a microfluidic channel so far, here we achieved it using precise feedback cell manipulation inside the microchannel. According to deformed shape and theoretically estimated shear force, we first obtained Young's modulus, consistent with that obtained in the previous methods with force sensors. In addition, conducting 'Loading examination' for the same RBC in the downstream of the microchannel, we succeeded in the estimation of absolute values of viscous and elastic constants of a RBC.
UR - http://www.scopus.com/inward/record.url?scp=85047008770&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2018.8346569
DO - 10.1109/MEMSYS.2018.8346569
M3 - Conference contribution
AN - SCOPUS:85047008770
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 388
EP - 391
BT - 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
Y2 - 21 January 2018 through 25 January 2018
ER -