MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression

Mu N. Liu; Shih Jen Tsai; Heng Liang Yeh; Chih Ching Wu; Ching Po Lin

doi:10.1080/13811118.2019.1649772

MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression

Mu N. Liu, Shih Jen Tsai, Heng Liang Yeh, Chih Ching Wu^*, Ching Po Lin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objectives: We compared serum levels of chemokines between male elders with major depressive disorder (MDD) and healthy controls, verifying whether any difference exists in the levels of these mediators between those with and without current suicidal ideation (SI). Methods: We enrolled 145 male elders aged 65 or older and analyzed 40 chemokines in patients with MDD with SI (n = 24) and without SI (n = 23), as well as healthy controls (n = 98). Results: The patients with MDD with SI presented higher levels of MCP-2/CCL8 (p ' 0.001) compared with the patients with MDD without SI and the healthy controls. Conclusions: Current findings suggest a potential role of MCP-2/CCL8 in suicidality among elderly males with depression.

Original language	English
Pages (from-to)	467-476
Number of pages	10
Journal	Archives of Suicide Research
Volume	24
Issue number	3
DOIs	https://doi.org/10.1080/13811118.2019.1649772
State	Published - 2 Jul 2020

Keywords

Chemokines
MCP-2/CCL8
elderly
major depressive disorder
suicide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/13811118.2019.1649772

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title = "MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression",

abstract = "Objectives: We compared serum levels of chemokines between male elders with major depressive disorder (MDD) and healthy controls, verifying whether any difference exists in the levels of these mediators between those with and without current suicidal ideation (SI). Methods: We enrolled 145 male elders aged 65 or older and analyzed 40 chemokines in patients with MDD with SI (n = 24) and without SI (n = 23), as well as healthy controls (n = 98). Results: The patients with MDD with SI presented higher levels of MCP-2/CCL8 (p ' 0.001) compared with the patients with MDD without SI and the healthy controls. Conclusions: Current findings suggest a potential role of MCP-2/CCL8 in suicidality among elderly males with depression.",

keywords = "Chemokines, MCP-2/CCL8, elderly, major depressive disorder, suicide",

author = "Liu, {Mu N.} and Tsai, {Shih Jen} and Yeh, {Heng Liang} and Wu, {Chih Ching} and Lin, {Ching Po}",

note = "Publisher Copyright: {\textcopyright} 2020 International Academy for Suicide Research.",

year = "2020",

month = jul,

day = "2",

doi = "10.1080/13811118.2019.1649772",

language = "English",

volume = "24",

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journal = "Archives of Suicide Research",

issn = "1381-1118",

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T1 - MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression

AU - Liu, Mu N.

AU - Tsai, Shih Jen

AU - Yeh, Heng Liang

AU - Wu, Chih Ching

AU - Lin, Ching Po

PY - 2020/7/2

Y1 - 2020/7/2

N2 - Objectives: We compared serum levels of chemokines between male elders with major depressive disorder (MDD) and healthy controls, verifying whether any difference exists in the levels of these mediators between those with and without current suicidal ideation (SI). Methods: We enrolled 145 male elders aged 65 or older and analyzed 40 chemokines in patients with MDD with SI (n = 24) and without SI (n = 23), as well as healthy controls (n = 98). Results: The patients with MDD with SI presented higher levels of MCP-2/CCL8 (p ' 0.001) compared with the patients with MDD without SI and the healthy controls. Conclusions: Current findings suggest a potential role of MCP-2/CCL8 in suicidality among elderly males with depression.

AB - Objectives: We compared serum levels of chemokines between male elders with major depressive disorder (MDD) and healthy controls, verifying whether any difference exists in the levels of these mediators between those with and without current suicidal ideation (SI). Methods: We enrolled 145 male elders aged 65 or older and analyzed 40 chemokines in patients with MDD with SI (n = 24) and without SI (n = 23), as well as healthy controls (n = 98). Results: The patients with MDD with SI presented higher levels of MCP-2/CCL8 (p ' 0.001) compared with the patients with MDD without SI and the healthy controls. Conclusions: Current findings suggest a potential role of MCP-2/CCL8 in suicidality among elderly males with depression.

KW - Chemokines

KW - MCP-2/CCL8

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KW - major depressive disorder

KW - suicide

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MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression

Abstract

Keywords

UN SDGs

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