Matrix-assisted laser desorption ionization-time of flight mass spectrometry accelerates pathogen identification and may confer benefit in the outcome of peritoneal dialysis-related peritonitis

Wei Hung Lin; Jyh Chang Hwang; Chin Chung Tseng; Yu Tzu Chang; An Bang Wu; Jing Jou Yan; Jiunn Jong Wu; Ming Cheng Wang

doi:10.1128/JCM.03378-15

Matrix-assisted laser desorption ionization-time of flight mass spectrometry accelerates pathogen identification and may confer benefit in the outcome of peritoneal dialysis-related peritonitis

Wei Hung Lin, Jyh Chang Hwang, Chin Chung Tseng, Yu Tzu Chang, An Bang Wu, Jing Jou Yan, Jiunn Jong Wu, Ming Cheng Wang^*

^*Corresponding author for this work

Department of Biotechnology and Laboratory Science in Medicine

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11 Scopus citations

Abstract

Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and conventional standard methods were compared for time to pathogen identification and impact on clinical outcomes in peritoneal dialysis-related peritonitis patients. The MALDI-TOF MS method identified the causative microorganisms earlier (average time saved, 64 h for all pathogens), and patients had a shorter hospital stay (mean±standard deviation, 5.2±4.8 days versus 8.2±4.5 days, P=0.001).

Original language	English
Pages (from-to)	1381-1383
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	54
Issue number	5
DOIs	https://doi.org/10.1128/JCM.03378-15
State	Published - May 2016

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Lin, W. H., Hwang, J. C., Tseng, C. C., Chang, Y. T., Wu, A. B., Yan, J. J., Wu, J. J., & Wang, M. C. (2016). Matrix-assisted laser desorption ionization-time of flight mass spectrometry accelerates pathogen identification and may confer benefit in the outcome of peritoneal dialysis-related peritonitis. Journal of Clinical Microbiology, 54(5), 1381-1383. https://doi.org/10.1128/JCM.03378-15

@article{5cb3a15f056b477b880f8623b417fc7e,

title = "Matrix-assisted laser desorption ionization-time of flight mass spectrometry accelerates pathogen identification and may confer benefit in the outcome of peritoneal dialysis-related peritonitis",

abstract = "Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and conventional standard methods were compared for time to pathogen identification and impact on clinical outcomes in peritoneal dialysis-related peritonitis patients. The MALDI-TOF MS method identified the causative microorganisms earlier (average time saved, 64 h for all pathogens), and patients had a shorter hospital stay (mean±standard deviation, 5.2±4.8 days versus 8.2±4.5 days, P=0.001).",

author = "Lin, {Wei Hung} and Hwang, {Jyh Chang} and Tseng, {Chin Chung} and Chang, {Yu Tzu} and Wu, {An Bang} and Yan, {Jing Jou} and Wu, {Jiunn Jong} and Wang, {Ming Cheng}",

year = "2016",

month = may,

doi = "10.1128/JCM.03378-15",

language = "English",

volume = "54",

pages = "1381--1383",

journal = "Journal of Clinical Microbiology",

issn = "0095-1137",

publisher = "American Society for Microbiology",

number = "5",

}

Lin, WH, Hwang, JC, Tseng, CC, Chang, YT, Wu, AB, Yan, JJ, Wu, JJ & Wang, MC 2016, 'Matrix-assisted laser desorption ionization-time of flight mass spectrometry accelerates pathogen identification and may confer benefit in the outcome of peritoneal dialysis-related peritonitis', Journal of Clinical Microbiology, vol. 54, no. 5, pp. 1381-1383. https://doi.org/10.1128/JCM.03378-15

Matrix-assisted laser desorption ionization-time of flight mass spectrometry accelerates pathogen identification and may confer benefit in the outcome of peritoneal dialysis-related peritonitis. / Lin, Wei Hung; Hwang, Jyh Chang; Tseng, Chin Chung et al.
In: Journal of Clinical Microbiology, Vol. 54, No. 5, 05.2016, p. 1381-1383.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Matrix-assisted laser desorption ionization-time of flight mass spectrometry accelerates pathogen identification and may confer benefit in the outcome of peritoneal dialysis-related peritonitis

AU - Lin, Wei Hung

AU - Hwang, Jyh Chang

AU - Tseng, Chin Chung

AU - Chang, Yu Tzu

AU - Wu, An Bang

AU - Yan, Jing Jou

AU - Wu, Jiunn Jong

AU - Wang, Ming Cheng

PY - 2016/5

Y1 - 2016/5

N2 - Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and conventional standard methods were compared for time to pathogen identification and impact on clinical outcomes in peritoneal dialysis-related peritonitis patients. The MALDI-TOF MS method identified the causative microorganisms earlier (average time saved, 64 h for all pathogens), and patients had a shorter hospital stay (mean±standard deviation, 5.2±4.8 days versus 8.2±4.5 days, P=0.001).

AB - Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and conventional standard methods were compared for time to pathogen identification and impact on clinical outcomes in peritoneal dialysis-related peritonitis patients. The MALDI-TOF MS method identified the causative microorganisms earlier (average time saved, 64 h for all pathogens), and patients had a shorter hospital stay (mean±standard deviation, 5.2±4.8 days versus 8.2±4.5 days, P=0.001).

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U2 - 10.1128/JCM.03378-15

DO - 10.1128/JCM.03378-15

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AN - SCOPUS:84964937836

SN - 0095-1137

VL - 54

SP - 1381

EP - 1383

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 5

ER -

Matrix-assisted laser desorption ionization-time of flight mass spectrometry accelerates pathogen identification and may confer benefit in the outcome of peritoneal dialysis-related peritonitis

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