Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis

Yung Hsiang Chen; Po Hsun Huang; Feng Yen Lin; Wen Chi Chen; Yuh Lien Chen; Wei Hsian Yin; Kee Ming Man; Po Len Liu

doi:10.1016/j.eujim.2011.09.002

Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis

Yung Hsiang Chen, Po Hsun Huang, Feng Yen Lin, Wen Chi Chen, Yuh Lien Chen, Wei Hsian Yin, Kee Ming Man, Po Len Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Introduction: Chinese herbs are widely used as important remedies in Oriental integrative medicine. Magnolol is a small polyphenolic molecule with low toxicity that is isolated from the herb genus Magnolia. In preclinical experiments, magnolol was found to have anti-oxidative, anti-inflammatory, anti-tumorigenic, anti-diabetic, anti-microbial, anti-neurodegenerative and anti-depressant properties. Magnolol can also effectively regulate pain control, hormonal signalling, gastrointestinal and uterus modulation as well as provide cardiovascular and liver protective effects. Materials and methods: We briefly conducted PubMed and MEDLINE database reviews for articles that related to magnolol. Results: The major biological mechanisms of action and potential health benefits of magnolol are described. Conclusions: These health benefits of magnolol have provided an increased interest in bringing this herbal compound to the clinic as a novel therapeutic agent. Knowledge of the multiple activities of magnolol can assist with the development of magnolol derivatives and the design of clinical trials that will maximize the potential benefit of magnolol in the patient setting.

Original language	English
Pages (from-to)	e317-e324
Journal	European Journal of Integrative Medicine
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/j.eujim.2011.09.002
State	Published - Dec 2011

Keywords

Antioxidant
Chinese medicine
Inflammation
Integrative medicine
Magnolol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.eujim.2011.09.002

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title = "Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis",

abstract = "Introduction: Chinese herbs are widely used as important remedies in Oriental integrative medicine. Magnolol is a small polyphenolic molecule with low toxicity that is isolated from the herb genus Magnolia. In preclinical experiments, magnolol was found to have anti-oxidative, anti-inflammatory, anti-tumorigenic, anti-diabetic, anti-microbial, anti-neurodegenerative and anti-depressant properties. Magnolol can also effectively regulate pain control, hormonal signalling, gastrointestinal and uterus modulation as well as provide cardiovascular and liver protective effects. Materials and methods: We briefly conducted PubMed and MEDLINE database reviews for articles that related to magnolol. Results: The major biological mechanisms of action and potential health benefits of magnolol are described. Conclusions: These health benefits of magnolol have provided an increased interest in bringing this herbal compound to the clinic as a novel therapeutic agent. Knowledge of the multiple activities of magnolol can assist with the development of magnolol derivatives and the design of clinical trials that will maximize the potential benefit of magnolol in the patient setting.",

keywords = "Antioxidant, Chinese medicine, Inflammation, Integrative medicine, Magnolol",

author = "Chen, {Yung Hsiang} and Huang, {Po Hsun} and Lin, {Feng Yen} and Chen, {Wen Chi} and Chen, {Yuh Lien} and Yin, {Wei Hsian} and Man, {Kee Ming} and Liu, {Po Len}",

note = "Funding Information: Grants NSC 100-2320-B-039-008-MY2 and NSC 100-2320-B-037-009 from the National Science Council , grant CMU100-NSC-05 from China Medical University , and grant DOH100-TD-B-111-004 from the Taiwan Department of Health Clinical Trial and Research Center of Excellence . ",

year = "2011",

month = dec,

doi = "10.1016/j.eujim.2011.09.002",

language = "English",

volume = "3",

pages = "e317--e324",

journal = "European Journal of Integrative Medicine",

issn = "1876-3820",

publisher = "Elsevier GmbH",

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}

TY - JOUR

T1 - Magnolol

T2 - A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis

AU - Chen, Yung Hsiang

AU - Huang, Po Hsun

AU - Lin, Feng Yen

AU - Chen, Wen Chi

AU - Chen, Yuh Lien

AU - Yin, Wei Hsian

AU - Man, Kee Ming

AU - Liu, Po Len

N1 - Funding Information: Grants NSC 100-2320-B-039-008-MY2 and NSC 100-2320-B-037-009 from the National Science Council , grant CMU100-NSC-05 from China Medical University , and grant DOH100-TD-B-111-004 from the Taiwan Department of Health Clinical Trial and Research Center of Excellence .

PY - 2011/12

Y1 - 2011/12

N2 - Introduction: Chinese herbs are widely used as important remedies in Oriental integrative medicine. Magnolol is a small polyphenolic molecule with low toxicity that is isolated from the herb genus Magnolia. In preclinical experiments, magnolol was found to have anti-oxidative, anti-inflammatory, anti-tumorigenic, anti-diabetic, anti-microbial, anti-neurodegenerative and anti-depressant properties. Magnolol can also effectively regulate pain control, hormonal signalling, gastrointestinal and uterus modulation as well as provide cardiovascular and liver protective effects. Materials and methods: We briefly conducted PubMed and MEDLINE database reviews for articles that related to magnolol. Results: The major biological mechanisms of action and potential health benefits of magnolol are described. Conclusions: These health benefits of magnolol have provided an increased interest in bringing this herbal compound to the clinic as a novel therapeutic agent. Knowledge of the multiple activities of magnolol can assist with the development of magnolol derivatives and the design of clinical trials that will maximize the potential benefit of magnolol in the patient setting.

AB - Introduction: Chinese herbs are widely used as important remedies in Oriental integrative medicine. Magnolol is a small polyphenolic molecule with low toxicity that is isolated from the herb genus Magnolia. In preclinical experiments, magnolol was found to have anti-oxidative, anti-inflammatory, anti-tumorigenic, anti-diabetic, anti-microbial, anti-neurodegenerative and anti-depressant properties. Magnolol can also effectively regulate pain control, hormonal signalling, gastrointestinal and uterus modulation as well as provide cardiovascular and liver protective effects. Materials and methods: We briefly conducted PubMed and MEDLINE database reviews for articles that related to magnolol. Results: The major biological mechanisms of action and potential health benefits of magnolol are described. Conclusions: These health benefits of magnolol have provided an increased interest in bringing this herbal compound to the clinic as a novel therapeutic agent. Knowledge of the multiple activities of magnolol can assist with the development of magnolol derivatives and the design of clinical trials that will maximize the potential benefit of magnolol in the patient setting.

KW - Antioxidant

KW - Chinese medicine

KW - Inflammation

KW - Integrative medicine

KW - Magnolol

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U2 - 10.1016/j.eujim.2011.09.002

DO - 10.1016/j.eujim.2011.09.002

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AN - SCOPUS:82455208877

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JO - European Journal of Integrative Medicine

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ER -

Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis

Abstract

Keywords

UN SDGs

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