Lyophilized particles and ethanolic extracts of Antrodia cinnamomea mycelia suppress the tumorigenicity of head and neck cancer cells in vivo

Ching Wen Chang, Yu Syuan Chen, Chien Chih Chen, Chin Chu Chen, Sen Je Sheu, Ting Wei Lin, Te Chang Lee, Jeng Fan Lo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Head and neck cancer (HNC) is one of the most common forms of cancer in Taiwan. In addition, head and neck cancer cells (HNCs) are highly tumorigenic and resistant to conventional therapy. Therefore, development of new therapeutic regimens that are adjuvant to conventional treatments would benefit future head and neck cancer therapy. In this study, we found that the lyophilized particles and ethanolic extracts of Antrodia cinnamomea mycelia inhibited the tumor growth of HNCs by xenograft assay in vivo. Moreover, administration of lyophilized particles or ethanolic extracts to nude mice did not cause significant side effects. Our study revealed that the Antrodia cinnamomea mycelia extract (ACME) efficiently inhibited the tumorigenicity of HNCs without causing organ failure. Furthermore, it showed that ACME may work as a novel drug candidate for alternative treatments for head and neck cancer.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalBioMedicine (Taiwan)
Volume4
Issue number4
DOIs
StatePublished - 1 Dec 2014

Keywords

  • Antrodia cinnamomea
  • Head and neck cancer

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