Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: A 10-year nationwide study

W. C. Fan; C. J. Liu; Y. C. Hong; J. Y. Feng; W. J. Su; S. H. Chien; T. J. Chen; C. H. Chiang

doi:10.5588/ijtld.14.0301

Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: A 10-year nationwide study

W. C. Fan, C. J. Liu, Y. C. Hong, J. Y. Feng, W. J. Su, S. H. Chien, T. J. Chen, C. H. Chiang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

BACKGROUND: Tuberculosis (TB) is a serious problem for patients undergoing haematopoietic stem cell transplantation (HSCT) in TB-endemic areas; however, data on these patients are limited.

METHODS: We obtained data on 2040 HSCTrecipients from the Registry of Catastrophic Illness in Taiwan from 1997 to 2006. We also obtained data on age-, sex- and enrolment date-matched controls from the Longitudinal Health Insurance Database. The cumulative incidence of active TB in HSCT recipients and controls and risk factors for TB were analysed.

RESULTS: Among 2040 HSCT recipients identified, 39 (1.9%) had newly diagnosed TB. The incidence rate was 688 per 100 000 person-years. The 10-year cumulative TB incidence was respectively 3.52% and 0.38% in HSCTrecipients and controls (P < 0.001). HSCTwas an independent risk factor for TB compared with matched controls. Among post-HSCT patients, independent risk factors for TB included age ≥18 years and allogeneic recipients with graft-versus-host disease (GVHD). Post-HSCT patients with subsequent TB had a higher mortality rate than those without TB (P < 0.001).

CONCLUSION: HSCT is associated with an increased risk of TB in endemic regions. Older age and development of chronic GVHD are independent predictors of late onset active TB in HSCT recipients.

Original language	English
Pages (from-to)	58-64
Number of pages	7
Journal	International Journal of Tuberculosis and Lung Disease
Volume	19
Issue number	1
DOIs	https://doi.org/10.5588/ijtld.14.0301
State	Published - 1 Jan 2015

Keywords

Graft-vs.-host disease
HSCT
Mortality
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: A 10-year nationwide study",

abstract = "BACKGROUND: Tuberculosis (TB) is a serious problem for patients undergoing haematopoietic stem cell transplantation (HSCT) in TB-endemic areas; however, data on these patients are limited.METHODS: We obtained data on 2040 HSCTrecipients from the Registry of Catastrophic Illness in Taiwan from 1997 to 2006. We also obtained data on age-, sex- and enrolment date-matched controls from the Longitudinal Health Insurance Database. The cumulative incidence of active TB in HSCT recipients and controls and risk factors for TB were analysed.RESULTS: Among 2040 HSCT recipients identified, 39 (1.9%) had newly diagnosed TB. The incidence rate was 688 per 100 000 person-years. The 10-year cumulative TB incidence was respectively 3.52% and 0.38% in HSCTrecipients and controls (P < 0.001). HSCTwas an independent risk factor for TB compared with matched controls. Among post-HSCT patients, independent risk factors for TB included age ≥18 years and allogeneic recipients with graft-versus-host disease (GVHD). Post-HSCT patients with subsequent TB had a higher mortality rate than those without TB (P < 0.001).CONCLUSION: HSCT is associated with an increased risk of TB in endemic regions. Older age and development of chronic GVHD are independent predictors of late onset active TB in HSCT recipients.",

keywords = "Graft-vs.-host disease, HSCT, Mortality, Tuberculosis",

author = "Fan, {W. C.} and Liu, {C. J.} and Hong, {Y. C.} and Feng, {J. Y.} and Su, {W. J.} and Chien, {S. H.} and Chen, {T. J.} and Chiang, {C. H.}",

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T1 - Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients

T2 - A 10-year nationwide study

AU - Fan, W. C.

AU - Liu, C. J.

AU - Hong, Y. C.

AU - Feng, J. Y.

AU - Su, W. J.

AU - Chien, S. H.

AU - Chen, T. J.

AU - Chiang, C. H.

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N2 - BACKGROUND: Tuberculosis (TB) is a serious problem for patients undergoing haematopoietic stem cell transplantation (HSCT) in TB-endemic areas; however, data on these patients are limited.METHODS: We obtained data on 2040 HSCTrecipients from the Registry of Catastrophic Illness in Taiwan from 1997 to 2006. We also obtained data on age-, sex- and enrolment date-matched controls from the Longitudinal Health Insurance Database. The cumulative incidence of active TB in HSCT recipients and controls and risk factors for TB were analysed.RESULTS: Among 2040 HSCT recipients identified, 39 (1.9%) had newly diagnosed TB. The incidence rate was 688 per 100 000 person-years. The 10-year cumulative TB incidence was respectively 3.52% and 0.38% in HSCTrecipients and controls (P < 0.001). HSCTwas an independent risk factor for TB compared with matched controls. Among post-HSCT patients, independent risk factors for TB included age ≥18 years and allogeneic recipients with graft-versus-host disease (GVHD). Post-HSCT patients with subsequent TB had a higher mortality rate than those without TB (P < 0.001).CONCLUSION: HSCT is associated with an increased risk of TB in endemic regions. Older age and development of chronic GVHD are independent predictors of late onset active TB in HSCT recipients.

AB - BACKGROUND: Tuberculosis (TB) is a serious problem for patients undergoing haematopoietic stem cell transplantation (HSCT) in TB-endemic areas; however, data on these patients are limited.METHODS: We obtained data on 2040 HSCTrecipients from the Registry of Catastrophic Illness in Taiwan from 1997 to 2006. We also obtained data on age-, sex- and enrolment date-matched controls from the Longitudinal Health Insurance Database. The cumulative incidence of active TB in HSCT recipients and controls and risk factors for TB were analysed.RESULTS: Among 2040 HSCT recipients identified, 39 (1.9%) had newly diagnosed TB. The incidence rate was 688 per 100 000 person-years. The 10-year cumulative TB incidence was respectively 3.52% and 0.38% in HSCTrecipients and controls (P < 0.001). HSCTwas an independent risk factor for TB compared with matched controls. Among post-HSCT patients, independent risk factors for TB included age ≥18 years and allogeneic recipients with graft-versus-host disease (GVHD). Post-HSCT patients with subsequent TB had a higher mortality rate than those without TB (P < 0.001).CONCLUSION: HSCT is associated with an increased risk of TB in endemic regions. Older age and development of chronic GVHD are independent predictors of late onset active TB in HSCT recipients.

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KW - Mortality

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Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: A 10-year nationwide study

Abstract

Keywords

UN SDGs

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