Long-term prognosis in recipients of implantable cardioverter- defibrillators for secondary preventions in Taiwan - A multicenter registry study

Tze Fan Chao, Chih Hung Lai, Ta Chuan Tuan*, Tsu Juey Wu, Jin Long Huang, Chuen Wang Chiou, Hsiang Chiang Hsiao, Yenn Jiang Lin, Jo Nan Liao, Chi Woon Kong, Shih Ann Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: The use of an implantable cardioverter-defibrillator (ICD) has a proven capacity to prevent sudden cardiac death (SCD), and can also improve survival duration in well-selected patients. The goal of the present study was to investigate the long-term prognosis and predictors of mortalities among ICD recipients in Taiwan. Methods: From 1998 to 2009, 238 consecutive patients who experienced SCDs or life-threatening ventricular tachyarrhythmias without correctable causes and received ICD implantations in 3 medical centers (Taipei, Taichung and Kaohsiung Veterans General Hospital) were enrolled in this study. The clinical endpoint was defined as the occurrence of all-cause mortality during the follow-up. Results: The mean age of the patientswas 63.0 ± 15.3 years, and 76.5% of them were male. Ischemic cardiomyopathy was the leading cause for the ICD implantations (39.1%). During the mean follow-up duration of 36.8 ± 29.8 months, there were 48 patients (20.2%) who died. Patients with structural heart diseases had a higher mortality rate than those without such diseases. Additionally, old age, low left ventricular ejection fraction (LVEF) and a history of diabetes mellitus (DM) were significant predictors of mortality. The optimal cutoff values for age (70 years) and LVEF (40%) in predicting mortality were further identified using the receiver operating characteristic curves. Conclusions: Based on the ICD registry from 3 medical centers in Taiwan, the annual mortality rate was around 6.6% and was higher in those patients with structural heart diseases. We observed that old age, low LVEF and a history of DM were significant predictors of mortality.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalActa Cardiologica Sinica
Volume30
Issue number1
StatePublished - Jan 2014

Keywords

  • Implantable cardioverter-defibrillator
  • Mortality
  • Predictor
  • Taiwan

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