Long-term mortality and cardiovascular outcomes in patients with atrial flutter after catheter ablation

Dony Yugo, Yun Yu Chen, Yenn Jiang Lin, Kuo Liong Chien, Shih Lin Chang, Li Wei Lo, Yu Feng Hu, Tze Fan Chao, Fa Po Chung, Jo Nan Liao, Ting Yung Chang, Chin Yu Lin, Ta Chuan Tuan, Ling Kuo, Cheng I. Wu, Chih Min Liu, Shin Huei Liu, Cheng Hung Li, Yu Cheng Hsieh, Shih Ann Chen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


AIMS: For patients with typical and atypical atrial flutter (AFL) but without history of atrial fibrillation (AF), the long-term cardiovascular (CV) outcomes after catheter ablation for AFL remain unclear. We compared the long-term all-cause mortality and CV outcomes in patients with AFL receiving catheter ablation compared with the results with medical therapy. METHODS AND RESULTS: Atrial flutter patients receiving catheter ablation for typical AFL were identified using the Health Insurance Database, and constituted the 'AFL ablation group'. Patients with typical and atypical AFL but without ablation (AFL without ablation group) were propensity matched to the AFL ablation group. Patients with prior AF diagnosis were excluded. Primary outcomes included all-cause and CV mortality, heart failure (HF) hospitalization, and stroke. The multivariable cox hazards regression model was used to evaluate the hazard ratio (HR) for study outcomes. A total of 3784 AFL patients (1892 patients in each group) was studied. Their mean follow-up durations were 7.85 ± 2.57 years (AFL without ablation group) and 8.31 ± 4.53 years (AFL ablation group). Atrial flutter with ablation patients had lower risks of all-cause mortality (HR: 0.68, P < 0.001), CV deaths (HR: 0.78, P = 0.001), HF hospitalization (HR: 0.84, P = 0.01), and stroke (HR: 0.80, P = 0.01). CONCLUSIONS: Catheter ablation for AFL in patients without prior AF was associated with lower risks of all-cause mortality and CV events compared with AFL patients without ablation during long-term follow-ups.

Original languageEnglish
Pages (from-to)970-978
Number of pages9
Issue number6
StatePublished - 15 Jul 2022


  • Ablation
  • Atrial fibrillation
  • Atrial flutter
  • Cardiovascular outcome


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