Locational effects on oral microbiota among long-term care patients

Fa Tzu Tsai*, Ding-Han Wang*, Cheng-Chieh Yang, Yu Cheng Lin, Lin Jack Huang, Wei Yu Tsai, Chang Wei Li, Wun Eng Hsu, Hsi-Feng Tu*, Ming-Lun Hsu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Dysbiosis of oral microbiota is the cause of many diseases related to oral and general health. However, few Asia-based studies have evaluated the role of oral microbiota in patients receiving long-term care. Thus, new indications are needed for early prevention and risk management based on information derived from the oral microbiota. Methods: We used next-generation sequencing (NGS) to identify the oral bacterial composition and abundance in patients receiving long-term care: 20 from the outpatient department (OPD) and 20 home-care patients. Their microbial compositions, taxonomy, and alpha/beta diversity were characterized. Results: Microbiota from the two groups showed different diversity and homogeneity, as well as distinct bacterial species. A more diverse and stable microbial population was observed among OPD patients. Our findings indicated that home-care patients had a higher risk of oral diseases due to the existence of dominant species and a less stable microbial community. Conclusion: This work was the first in Taiwan to use NGS to investigate the oral microbiota of long-term care patients. Our study demonstrated the potential use of dominant bacterial species as biomarkers for the risk management of posttreatment complications.

Original languageEnglish
Article number2033003
JournalJournal of Oral Microbiology
Issue number1
StatePublished - Feb 2022


  • Oral microbiota
  • home care
  • long-term care patients
  • next-generation sequencing (NGS)
  • outpatient department (OPD)


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