Living donor liver transplantation for small infants aged less than 6 months: The experience of a single institute

Yi Ting Yeh, Chinsu Liu*, Hsin Lin Tsai, Cheng Yen Chen, Niang Cheng Lin, Jei Wen Chang, Pei Chen Tsao, Yu Sheng Lee, Cheng Yuan Hsia, Che Chuan Loong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Purpose: Liver transplantation (LT) for small infants < 6 months old is rare but becoming common as perioperative care improves. In Taiwan, living donor LT (LDLT) has expanded indications but is rarely performed for this age group because of unfavorable outcomes in the literature. We evaluated LDLT outcomes of patients <6 months old. Methods: We identified infants < 6 months old undergoing LDLT between 2004 and 2019 at our hospital. Variables related to recipients, donors, surgeries, and outcomes were analyzed. Results: Nine patients were identified. Indications for LT were biliary atresia (n = 2), Alagille syndrome (n = 1), protein C deficiency (n = 1), and acute liver failure (n = 5), including two patients with neonatal hemochromatosis, one with herpes simplex hepatitis, one with giant cell hepatitis with autoimmune hemolytic anemia, and one with hemophagocytic lymphohistiocytosis. Median age and weight at LT were 129 days and 4.8 kg, respectively. Graft types included left lateral segment (LLS, n = 4), hyper-reduced LLS (n = 4), and monosegment (n = 1). The median graft-to-recipient weight ratio was 4%. The median follow-up period was 14 months (range, 8 days to 127 months) with two mortalities, and two patients were totally weaned off immunosuppressants. Adjuvant therapies were required for patients with giant cell hepatitis and hemophagocytosis. Preoperative reconstructive imaging for estimating graft thickness facilitated surgical planning. Conclusion: Although LDLT is difficult to perform for small infants, outcomes are favorable and mainly dependent on underlying causes in addition to technical innovations.

Original languageEnglish
Pages (from-to)1157-1161
Number of pages5
JournalJournal of Pediatric Surgery
Volume56
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • Graft versus weight ratio
  • Graft volume reduction
  • Liver transplantation
  • Living donor liver transplantation
  • Monosegmental graft
  • Pediatric liver transplantation

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