Litebamine N-homologues: Preparation and anti-acetylcholinesterase activity

Chi Ming Chiou; Jaw Jou Kang; Shoei Sheng Lee

doi:10.1021/np970298f

Litebamine N-homologues: Preparation and anti-acetylcholinesterase activity

Chi Ming Chiou, Jaw Jou Kang, Shoei Sheng Lee^*

^*Corresponding author for this work

Institute of Food Safety and Health Risk Assessment

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Litebamine N-homologues were easily prepared from laurolitsine, generally via three reaction steps (N-alkylation, solvolysis with 1 M NH₄OAc under reflux, and the Mannich reaction) in more than 80% overall yield. Among the prepared compounds, N-propyl-, N-isobutyl-, and N-isopropylnorlitebamines exhibited moderate antiacetylcholinesterase activity (IC₅₀ ca. 7.0 μM), while the corresponding N-metho salt of N-propylnorlitebamine showed potent activity (IC₅₀ 2.70 μM).

Original language	English
Pages (from-to)	46-50
Number of pages	5
Journal	Journal of Natural Products
Volume	61
Issue number	1
DOIs	https://doi.org/10.1021/np970298f
State	Published - Jan 1998

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title = "Litebamine N-homologues: Preparation and anti-acetylcholinesterase activity",

abstract = "Litebamine N-homologues were easily prepared from laurolitsine, generally via three reaction steps (N-alkylation, solvolysis with 1 M NH4OAc under reflux, and the Mannich reaction) in more than 80% overall yield. Among the prepared compounds, N-propyl-, N-isobutyl-, and N-isopropylnorlitebamines exhibited moderate antiacetylcholinesterase activity (IC50 ca. 7.0 μM), while the corresponding N-metho salt of N-propylnorlitebamine showed potent activity (IC50 2.70 μM).",

author = "Chiou, {Chi Ming} and Kang, {Jaw Jou} and Lee, {Shoei Sheng}",

year = "1998",

month = jan,

doi = "10.1021/np970298f",

language = "English",

volume = "61",

pages = "46--50",

journal = "Journal of Natural Products",

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AU - Chiou, Chi Ming

AU - Kang, Jaw Jou

AU - Lee, Shoei Sheng

PY - 1998/1

Y1 - 1998/1

N2 - Litebamine N-homologues were easily prepared from laurolitsine, generally via three reaction steps (N-alkylation, solvolysis with 1 M NH4OAc under reflux, and the Mannich reaction) in more than 80% overall yield. Among the prepared compounds, N-propyl-, N-isobutyl-, and N-isopropylnorlitebamines exhibited moderate antiacetylcholinesterase activity (IC50 ca. 7.0 μM), while the corresponding N-metho salt of N-propylnorlitebamine showed potent activity (IC50 2.70 μM).

AB - Litebamine N-homologues were easily prepared from laurolitsine, generally via three reaction steps (N-alkylation, solvolysis with 1 M NH4OAc under reflux, and the Mannich reaction) in more than 80% overall yield. Among the prepared compounds, N-propyl-, N-isobutyl-, and N-isopropylnorlitebamines exhibited moderate antiacetylcholinesterase activity (IC50 ca. 7.0 μM), while the corresponding N-metho salt of N-propylnorlitebamine showed potent activity (IC50 2.70 μM).

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JO - Journal of Natural Products

JF - Journal of Natural Products

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ER -

Litebamine N-homologues: Preparation and anti-acetylcholinesterase activity

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