Linkage analyses of markers on chromosome 15q with schizophrenia in Taiwanese families

C. M. Liu*, M. W. Lin, H. G. Hwu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Linkage of a neurophysiological deficit associated with schizophrenia, i.e. the failure to inhibit the auditory P50 response, was previously reported at chromosome 15q14. A small positive lod score was also reported when examined for linkage to the schizophrenia phenotype (Freedman et al, 1997). Follow up studies revealed contradictory results (Leonard et al,1998; Neves-Pereira et al, 1998; Curtis et al, 1999). In an attempt to test this possible linkage evidence in an ethnically different sample, we studied the linkage of schizophrenia with three markers on chromosome 15q13-14 in 51 Taiwanese schizophrenic nuclear families with at least two affected siblings. Two diagnostic models (narrow: DSM-IV schizophrenia only; and broad: including schizophrenia, schizoaffective, and other non-affective psychotic disorders) were used to define the disease phenotype. With the narrow/ recessive model, the marker D15S165 produced maximum two-point lod score of 1.46 (=0.1). Assuming locus heterogeneity, a multipoint lod score of 0.47 (=0.24) was obtained at the marker D15S165 under narrow/recessive model. Maximum nonparametric score of 2.44 (p=0.007) and 2.12 (p=0.01) were obtained at marker D15S165 under broad and narrow model respectively. The results support the suggestive linkage evidence of schizophrenia with markers on 15q13-14 in an ethnically distinct Taiwanese sample.

Original languageEnglish
Pages (from-to)550
Number of pages1
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume96
Issue number4
StatePublished - 7 Aug 2000

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