LED induced autofluorescence (LIAF) imager with eight multi-filters for oral cancer diagnosis

Ting Wei Huang*, Nai Lun Cheng, Ming Hsui Tsai, Jin-Chern Chiou, Yang-Mang Ou

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Oral cancer is one of the serious and growing problem in many developing and developed countries. The simple oral visual screening by clinician can reduce 37,000 oral cancer deaths annually worldwide. However, the conventional oral examination with the visual inspection and the palpation of oral lesions is not an objective and reliable approach for oral cancer diagnosis, and it may cause the delayed hospital treatment for the patients of oral cancer or leads to the oral cancer out of control in the late stage. Therefore, a device for oral cancer detection are developed for early diagnosis and treatment. A portable LED Induced autofluorescence (LIAF) imager is developed by our group. It contained the multiple wavelength of LED excitation light and the rotary filter ring of eight channels to capture ex-vivo oral tissue autofluorescence images. The advantages of LIAF imager compared to other devices for oral cancer diagnosis are that LIAF imager has a probe of L shape for fixing the object distance, protecting the effect of ambient light, and observing the blind spot in the deep port between the gumsgingiva and the lining of the mouth. Besides, the multiple excitation of LED light source can induce multiple autofluorescence, and LIAF imager with the rotary filter ring of eight channels can detect the spectral images of multiple narrow bands. The prototype of a portable LIAF imager is applied in the clinical trials for some cases in Taiwan, and the images of the clinical trial with the specific excitation show the significant differences between normal tissue and oral tissue under these cases.

Original languageEnglish
Title of host publicationDesign and Quality for Biomedical Technologies IX
EditorsRongguang Liang, Ramesh Raghavachari
ISBN (Electronic)9781628419344
StatePublished - 1 Jan 2016
EventDesign and Quality for Biomedical Technologies IX - San Francisco, United States
Duration: 13 Feb 201614 Feb 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceDesign and Quality for Biomedical Technologies IX
Country/TerritoryUnited States
CitySan Francisco


  • Autofluorescence
  • filter
  • induced
  • LED
  • oral cancer


Dive into the research topics of 'LED induced autofluorescence (LIAF) imager with eight multi-filters for oral cancer diagnosis'. Together they form a unique fingerprint.

Cite this