Laser irradiated growth of protein crystal

Hiroaki Adachi*, Kazufumi Takano, Youichiroh Hosokawa, Tsuyoshi Inoue, Yusuke Mori, Hiroyoshi Matsumura, Masashi Yoshimura, Yasuo Tsunaka, Masaaki Morikawa, Shigenori Kanaya, Hiroshi Masuhara, Yasushi Kai, Takatomo Sasaki

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

131 Scopus citations


We succeeded in the first ever generation of protein crystals by laser irradiation. We call this process Laser Irradiated Growth Technique (LIGHT). Effective crystallization was confirmed by applying an intense femtosecond laser. The crystallization period was dramatically shortened by LIGHT. In addition, protein crystals were obtained by LIGHT from normally uncrystallized conditions. These results indicate that intense femtosecond laser irradiation generates crystal nuclei; protein crystals can then be grown from the nuclei that act as seeds in a supersaturated solution. The nuclei formation is possible primarily due to nonlinear nucleation processes of an intense femtosecond laser with a peak intensity of over a gigawatt (GW).

Original languageEnglish
Pages (from-to)L798-L800
Number of pages3
JournalJapanese Journal of Applied Physics, Part 2: Letters
Issue number7 B
StatePublished - Jul 2003


  • Laser
  • Nucleation
  • Protein crystal
  • Short-pulse
  • Supersaturated solution


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