Langerhans Cell Histiocytosis in a Newborn

Tzu Ying Yang, Shu Jen Chen*, Ling Yu Yang, Ren Bin Tang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A full-term female baby was admitted to our hospital at the postnatal age of 37 days with generalized vesiculopapular, crateriform skin lesions. Physical examination revealed a well-nourished baby without fever, hepatosplenomegaly or lymphadenopathy. Laboratory examination was normal except for thrombocytosis (platelet count, 970 × 103/μL). All studies for herpes simplex virus, including culture, polymerase chain reaction and IgM, were negative except for an antigen test from the vesicles for herpes simplex virus type 1, which was positive. Chest X-ray showed increased reticulogranular infiltration over bilateral lung fields and some osteolytic lesions at the left parietal bone. Skin biopsy revealed infiltration of Langerhans cells and eosinophils, plus positive CD1a and S-100 stains. The diagnosis was reconfirmed by a second hospital and chemotherapy was given. In this case report, the differential diagnoses of neonatal vesiculopapular skin lesions, and the classification and outcome of neonatal Langerhans cell histiocytosis are presented.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalJournal of the Chinese Medical Association
Issue number11
StatePublished - Nov 2009


  • Langerhans cell histiocytosis
  • newborn
  • vesiculopapular skin lesion


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