Label-Free Uric Acid Estimation of Spot Urine Using Portable Device Based on UV Spectrophotometry

Tsung Jui Lin; Kai Ting Yen; Chien Fan Chen; Shuo Ting Yan; Kuan Wei Su; Ya Ling Chiang

doi:10.3390/s22083009

Label-Free Uric Acid Estimation of Spot Urine Using Portable Device Based on UV Spectrophotometry

Tsung Jui Lin, Kai Ting Yen, Chien Fan Chen, Shuo Ting Yan, Kuan Wei Su, Ya Ling Chiang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The maintenance of uric acid levels is crucial for the human body. In this study, the feasibility of using portable ultraviolet (UV) spectrophotometry to measure the uric acid of spot urine without the need to add reagents has been demonstrated for the first time. UV spectral analysis has been used to inspect the uric acid concentration in urine. It is found that the absorption spectrum of urine has a high correlation with the concentration of uric acid at a wavelength of around 290–300 nm. Uric acid levels measured with a spectral analyzer compared to uric acid concentrations measured with a traditional biochemical analysis showed good agreement. The portable prototype is label-free and capable of displaying the inspection result of each measurement within 10 s. In the long run, this device can assist people in checking uric acid levels of spot urine with higher frequency and can adjust diet or medication in real time for more efficient health management.

Original language	English
Article number	3009
Journal	Sensors
Volume	22
Issue number	8
DOIs	https://doi.org/10.3390/s22083009
State	Published - 1 Apr 2022

Keywords

spot urine
uric acid
UV spectrophotometry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/s22083009

Cite this

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title = "Label-Free Uric Acid Estimation of Spot Urine Using Portable Device Based on UV Spectrophotometry",

abstract = "The maintenance of uric acid levels is crucial for the human body. In this study, the feasibility of using portable ultraviolet (UV) spectrophotometry to measure the uric acid of spot urine without the need to add reagents has been demonstrated for the first time. UV spectral analysis has been used to inspect the uric acid concentration in urine. It is found that the absorption spectrum of urine has a high correlation with the concentration of uric acid at a wavelength of around 290–300 nm. Uric acid levels measured with a spectral analyzer compared to uric acid concentrations measured with a traditional biochemical analysis showed good agreement. The portable prototype is label-free and capable of displaying the inspection result of each measurement within 10 s. In the long run, this device can assist people in checking uric acid levels of spot urine with higher frequency and can adjust diet or medication in real time for more efficient health management.",

keywords = "spot urine, uric acid, UV spectrophotometry",

author = "Lin, {Tsung Jui} and Yen, {Kai Ting} and Chen, {Chien Fan} and Yan, {Shuo Ting} and Su, {Kuan Wei} and Chiang, {Ya Ling}",

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AU - Lin, Tsung Jui

AU - Yen, Kai Ting

AU - Chen, Chien Fan

AU - Yan, Shuo Ting

AU - Su, Kuan Wei

AU - Chiang, Ya Ling

PY - 2022/4/1

Y1 - 2022/4/1

N2 - The maintenance of uric acid levels is crucial for the human body. In this study, the feasibility of using portable ultraviolet (UV) spectrophotometry to measure the uric acid of spot urine without the need to add reagents has been demonstrated for the first time. UV spectral analysis has been used to inspect the uric acid concentration in urine. It is found that the absorption spectrum of urine has a high correlation with the concentration of uric acid at a wavelength of around 290–300 nm. Uric acid levels measured with a spectral analyzer compared to uric acid concentrations measured with a traditional biochemical analysis showed good agreement. The portable prototype is label-free and capable of displaying the inspection result of each measurement within 10 s. In the long run, this device can assist people in checking uric acid levels of spot urine with higher frequency and can adjust diet or medication in real time for more efficient health management.

AB - The maintenance of uric acid levels is crucial for the human body. In this study, the feasibility of using portable ultraviolet (UV) spectrophotometry to measure the uric acid of spot urine without the need to add reagents has been demonstrated for the first time. UV spectral analysis has been used to inspect the uric acid concentration in urine. It is found that the absorption spectrum of urine has a high correlation with the concentration of uric acid at a wavelength of around 290–300 nm. Uric acid levels measured with a spectral analyzer compared to uric acid concentrations measured with a traditional biochemical analysis showed good agreement. The portable prototype is label-free and capable of displaying the inspection result of each measurement within 10 s. In the long run, this device can assist people in checking uric acid levels of spot urine with higher frequency and can adjust diet or medication in real time for more efficient health management.

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KW - uric acid

KW - UV spectrophotometry

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Label-Free Uric Acid Estimation of Spot Urine Using Portable Device Based on UV Spectrophotometry

Abstract

Keywords

UN SDGs

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